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High fat diet mice obesity articles – Diet-induced obesity in animal models: points to consider and influence on metabolic markers

Mimicking such lipotoxic conditions in vitro was shown to inhibit the growth of murine secondary ovarian follicles during 13 days exposure and substantially reduced oocyte developmental capacity and the quality of the resulting blastocysts 6.

Ethan Walker
Tuesday, May 3, 2016
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  • This is the first study comparing different DIO diets for their effects on the coagulation system. In this section additional, tissue-specific analysis methods will also be listed and referenced or discussed.

  • This result may be attributable to reduced food intake Fig. This hypothesis requires further investigation.

  • The Journal of clinical investigation —

  • Furthermore, inbreeding increases the risk of genetic drift and persistent undiscovered mutations, which may confound responses to experimental factors

Journal of Diabetes Research

There might be certain studies investigating the effect of high fat intake in particular. Therefore the HFD is the most appropriate disease model [ 18 ]. Sheu, J. Application of high-throughput sequencing in understanding human oral microbiome related with health and disease.

Influence of dietary macronutrient composition on adiposity and cellularity of diferente fat depots in Wistar rats. Download PDF. Palmer, B. It seeks to identify which are the main methodological strategies to induce obesity through diet, as well as identifying which are the main parameters to be taken into account to achieve a successful model. Mol Nutr Food Res. Heart weight was normalized against tibia length [24]. Many therapeutics are being tested in the HFD protocol.

Akhmedov and R. Li et al. The chemistry of gut microbial metabolism of polyphenols. Ritchie and L. Articles in humans, in cell culture, in non-rodent animals, as well as review articles, articles that did not have obesity induction and book chapters were also excluded.

Introduction

This is an inbred strain which progressively gain weight 81114 and develop hyperlipidemia and inflammatory responses kbesity supplemented with HFD. Biochim Biophys Acta. Although the high fat diet increased the whole body mass Fig 1Bthe accumulation of intra-abdominal fat Fig 1Cand the percentages of total body fat and intra-abdominal fat Fig 1Dthose in 5-HT treated mice on the F diet were not different from the control mice on the Ch diet.

The hyperglycemia caused by the HFD signals the pancreas to secrete more and more insulin. Panel C shows the development of the bodyweight over time. In addition, a recent chapter has described the utility of mouse models for T2DM drug discovery [ 4 ]. Speakman and K.

Skip to main content Xiet you for visiting nature. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. J Sex Med. Klindworth A, et al. TPH2 is expressed entirely in neuronal cells, such as in the raphe nuclei of the brain stem. The resulting fermented food, which is known to be healthy and beneficial, has been shown to possess enhanced nutritional value and health benefits because of the production of unique organic compounds and secondary metabolites by microbiological action 4. However, the health benefits of Nipa vinegar, especially its anti-obesity effects, have not been evaluated previously.

Acknowledgements

The taste and texture of diets influence the amount of food consumed. In addition, studies have confirmed that sex-related differences are an important consideration in the study of gut microbiota. Likewise, serum concentration of cholesterol is also an important parameter for the assessment of obesity, since the greater the availability of serum cholesterol, the greater the deposition of fatty acids into the adipose tissue and the liver [ 33 ].

Study of the effects of nesfatin-1 on gastric function in obese rats. The concentration-dependent tat to acetylcholine 0. Stegenga, M. Flowchart for selecting articles. According to the inclusion and exclusion criteria Table 1articles were selected for full reading, articles were excluded and 20 articles were not available for reading, due to restricted access to their abstracts Fig. High-fat diets: modeling the metabolic disorders of human obesity in rodents.

Jarc, E. Reducing the leptin level has been linked to satiety hoghand the reduction in high fat diet mice obesity articles that results from the consumption of both vinegars was determined to be associated with reduced food intake in both SH- and NH-treated obese mice. This could be simply due to mitophagy and removal of damaged mitochondria. The effect was concentration-dependent when analyzed at 26 weeks of age. Everard A, et al. Whole-body energy metabolism was examined using an open-circuit indirect calorimeter Arco; Arco System, Chiba, Japan.

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Insulin usually reduces hepatic gluconeogenesis and glycogenolysis. Tran, and C. Dalby, M. Gut microbiota: a new path to treat obesity. As alterations are evidenced in the absence of ventricular dilatation, obese mice hearts underwent a concentric hypertrophy.

These polyphenolic acids, which are present in Nipa vinegar at high concentrations, may help to further improve the serum lipid profile and reduce BW compared to synthetic acetic acid vinegar. Therefore, a high population of Firmicutes in obese subjects was linked to extra energy extraction from non-digestible carbohydrates, which subsequently increased the amount of energy intake The standard curve of each product followed the calculation of the respective gene expressions. Obesity, the metabolic syndrome, and sexual dysfunction.

By submitting a comment you agree to abide by our Terms and Community Guidelines. Additionally, the mitochondria of the brown adipose tissue are also affect by DIO impairing glucose metabolism [ 51 ]. Kim, M. High-fat diets: modeling the metabolic disorders of human obesity in rodents.

  • Sims, M. A high-fat diet feeding induces hyperleptinemia both in mice and humans [28][35][36].

  • Gastrocnemius and soleus muscles obtained from 14 week old mice were frozen in acetone cooled by dry ice.

  • Mol Metab 6—

  • The Journal of Lipid Research.

Alterations in mitochondrial membrane potential during preimplantation stages mcie mouse and human embryo development. Mitochondrial morphology during preimplantational human embryogenesis. Immunohistochemical analysis Gastrocnemius and soleus muscles obtained from 14 week old mice were frozen in acetone cooled by dry ice. Reprints and Permissions. In conclusion, different important aspects of mitochondrial dysfunction in response to HFD-induced obesity appear to be influenced by the genetic background of the mouse model used, including alteration in MMP, mitochondrial ultrastructural abnormalities and alteration in mtDNA copy numbers and possibly mechanisms regulating mitochondrial biogenesis and mitophagy. Figure 1.

Figure 4. Circulation research — Sci Rep. However, it is not definitely established yet whether purified control diets are really superior to SCDs. Article PubMed Google Scholar

Introduction

Overweight and obesity are a worldwide public health problem. Considering that a spontaneous caloric increase is difficult to achieve in rodents, even when flavored diets are offered [ 6 ], DIO must have a high caloric density [ 1630 ]. Asha, R. Kesherwani, V.

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  • Figure 3. However, in Boudoures, et al.

  • Introduction Obesity and related metabolic diseases, which are caused by a high-fat diet HFD and sedentary lifestyle, have been increasing with the improvements in standard of living and the changing lifestyle and have become an urgent public health problem 1.

  • Insulin Sigma was administered i. Plos One.

  • In both B6 and Swiss HFD groups, it was noticed that many mitochondria had a relatively lower electron density, which was difficult to quantify.

Odom, M. Curzon G. Postgrad Med J. FEBS Lett —

You can also search for this author in PubMed Google Scholar. Accepted lbesity 13 April The sequencing data were subjected to quality data pre-processing with quality value 20 Q20 using a pair-end read merger. Frediani Brant, N. The genetic homogeneity in inbred strains minimizes variability in experimental settings. Alpha-linolenic acid protects the developmental capacity of bovine cumulus-oocyte complexes matured under lipotoxic conditions in vitro.

Densitometric analysis and protein semi-quantification were performed using ImageJ software [26]. Elegant rodent studies have demonstrated that SCFAs have a suppressive effect on appetite and energy intake via central nervous system-related mechanisms and the gut—brain axis 56 Chronic refined low-fat diet consumption reduces cholecystokinin satiation in rats. Hypertension-linked pathophysiological alterations in the gut.

Skip to main content Thank you for visiting nature. The gut microbiota as an environmental factor that regulates fat storage. After four hours of fasting, blood samples were collected from the tail vein of alert mice. Another review manuscript describes the use of HFD mice to identify factors involved in obesity resistance or sensitivity [ 43 ]. Diab Vasc Dis Res. Gomez-Hernandez, J.

You obssity using a browser version with limited support for CSS. In contrast, High fat diet mice obesity articles oocytes exhibited significantly higher proportion of abnormal mitochondria Although acetic acid has been proposed to be the main vinegar ingredient responsible for this anti-obesity effect 7different vinegars have manifested different bioactivities In addition, vinegar has also been shown to improve serum glucose levels and insulin resistance in patients with type 1 9 and type 2 diabetes 10 — Full size image. SREBP1 is a transcription factor involved in activating lipids and carbohydrate metabolism through glucose uptake

High fat diet mice obesity articles Funct. Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model. However, it remains unclear why 5-HT decreased body weight gain in mice on the F diet, but not on the Ch diet. All antagonists were i. However, there are few studies on an effect of an intestinal hormone on the ratio of muscle fiber type without the effect of exercise or the knockout of one or more genes.

Igosheva, N. However, the potential interplay of genetic background and the response to HFD-induced obesity at the oocyte level has not been described yet. However, almost all agonists and antagonists of 5HTR can pass the blood-brain barrier; 5-HT studies in the central nervous system have received a lot of attention in recent years. All procedures in this study were approved by the ethical committee of the University of Antwerp and performed accordingly ECD nr.

Shin J, et al. Because the alterations in the gut microbiota were similar in both SH-and High fat diet mice obesity articles mice, the organic acids, particularly acetic acid, may have been the major ingredients that contributed to these effect. Vinegar supplementation lowers glucose and insulin responses and increases satiety after a bread meal in healthy subjects. These reports indicate that metabolic regulation in mammals requires communication between multiple organs and tissues, and that 5-HT may prevent or even reverse fat accumulation and body weight gain after the consumption of surplus energy following F diet feeding.

ORIGINAL RESEARCH article

These authors identified strains that were susceptible and resistant to hippocampal dysfunction elicited by HFD [ 49 ]. The Journal of pathology — High-energy and HFD-induced weight gain and fat accumulation were inhibited in germ-free GF mice 89.

  • H—H,

  • Author information Article notes Copyright and License information Disclaimer.

  • The functional activity of coagulation factors was studied with assays modified from human clinical assays by mixing mouse plasma with factor-deficient human plasma Comparisons of diets used in animal models of high-fat feeding.

  • National Center for Biotechnology InformationU.

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Get the most important science stories of the day, free in your inbox. Published online Jul Genome Biol. Whereas in B6 oocytes, LDs were mostly found in large aggregated clusters Fig. Male mice had higher glucose intolerance, and Glrx1 deficiency aggravated gender differences in glucose intolerance.

ALSO READ: Fast Can Lose Weight Phentermine Diet

Mice fed with a high-fat diet for prolonged time recapitulates the etiology, course fwt outcomes of the early phases of human diabetic cardiomyopathy. T1—T23, At the onset of a HFD the murine adipose tissue adequately expands and stores the excess calories [ 56 ]. Reddy, M. Diet dominates host genotype in shaping the murine gut microbiota.

This is consistent with hlgh studies 46. Impacts on cognition with age appear relatively minor [ 45 ]. Int J Obes Lond. Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue. Commonly chow diets are grain-based and supplemented with fats, vitamins and minerals

  • Search Search articles by subject, keyword or author.

  • These results should create awareness when choosing and interpreting data obtained from different mouse models before extrapolating to human applications.

  • Influence of dietary macronutrient composition on adiposity and cellularity of diferente fat depots in Wistar rats.

  • This accumulation in organs other than the adipose tissue, such as the liver, can also lead to insulin resistance and hyperglycemia, since saturated fatty acids interfere in the activity of insulin receptor and glucose transporters [ 23 ].

  • Lorenz JN, Robbins J Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse. Hemodynamic parameters were measured by cardiac catheterization [20][21].

Therefore overall changes in the MMP in oocytes should always be carefully interpreted in the context of other related parameters and considering the associated ROS levels. Genome Biol. Int J Impot Res Noorjahan Banu Alitheen, Email: ym. Plos One.

Increasing autophagy can alleviate many of the HFD-mediated pathologies [ 9293 ]. H—H, View author publications. Although there has been speculation that sucrose with or without fat should also cause T2DM, this has not been found. Perrard, J. Lu, and F.

Surprisingly, several oxidative stress related transcripts were upregulated in control B6 oocytes when compared to the Swiss control group Fig. Meanwhile, the diet mice containing the detached cumulus cells from all animals in each subgroup were also immediately pooled, centrifuged, washed in PBS-PVP and snap frozen. Accumulation of LD in non-adipose tissue is a cellular mechanism that prevents lipotoxicity by storing intracellular lipids in a neutral status These effects were highly dependent on the strain. However, almost all agonists and antagonists of 5HTR can pass the blood-brain barrier; 5-HT studies in the central nervous system have received a lot of attention in recent years.

  • Hermes et al.

  • E, The adipose tissues of mice at 26 weeks of age were stained with hematoxylin and eosin. In contrast, high MMP can also be detrimental, and was linked with increased embryonic arrest at the 2-cell stage in mice and with high fragmentation rate in 8-cell embryos in humans

  • In humans there is retrospective epidemiological evidence that sucrose is not causative to T2DM [ 77 ].

  • The major components of both the standard pellet diet and HFD are listed in Table 2.

A couple of the responses concerned the issue that the DIO series of diets differ not only in their fat content but also in other components that may be important in terms of driving effects on metabolic health. Kumon, and K. Correlation analysis showed that there was a significant positive correlation between Dehalobacterium, Oscillospira, Muribaculaceae, rcand Oscillospira and LBP, which was reduced by supplementation with HON compared to the HFD-fed group of mice. It was shown that, in dependency of the level and type of fibre in a diet, gut morphology and microbiome varied in mice Those factors promote lipid utilization as an energy substrate for mitochondrial oxidation. In addition, the HFD-fed group of female mice did not have an increased abundance of Oscillospira compared with male mice. For calculation of the caloric uptake, the consumed food in gram was multiplied with the calories per gram of the respective type of food.

  • Next, it was dehydrated with ethanol and mounted in paraffin. Med Princ Pract.

  • In Swiss control oocytes,

  • Baltgalvis, K. Mice were euthanized and heart and tibia were dissected.

  • After reading the selected articles, one additional article was included in the study, totaling 35 articles Fig. Fan X, Wu X The first line of defense against cardiac hypertrophy.

Diet-induced obesity model: abnormal oocytes and persistent mice obesity articles abnormalities in the offspring. In vivo matured oocytes were obtained from the oviducts immediately after euthanasia. Therefore, detection of these changes in HFD oocytes here may indicate a premature alteration in cellular metabolism. Introduction The prevalence of obesity and metabolic syndrome is increasing and is currently affecting millions of women in reproductive age worldwide. The notion that B6 control oocytes also suffer from oxidative stress was further supported by the gene expression results and other outcome parameters as discussed below. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. Female obesity adversely affects assisted reproductive technology ART pregnancy and live birth rates.

J Funct Foods. Sci Rep 10, It has been previously reported that neural 5-HT has a suppressive effect on food intake and tends to decrease body weight gain [ 5 — 10 ]. We hypothesized that the mouse genetic background can influence the impact of high fat diet HFD -induced obesity on oocyte quality. RSC Advance.

In conclusion, we show evidence that the genetic background or inbreeding can affect mitochondrial functions in oocytes and may influence the impact of HFD on high fat diet mice obesity articles quality. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Clinical evidence has correlated obesity with increased Firmicutes and decreased Bacteroidetes and Verrucomicrobia populations in the gut We showed that the outbred Swiss mouse seems to be more sensitive to HFD-induced reduction in oocyte quality when compared to the inbred B6 mouse.

  • Bortolin, R.

  • Clin Neuropharmacol S51—

  • Effect of HON on adipose mass gain. The gold standard for body composition is an MRI.

  • After 12 weeks, ex vivo vascular reactivity was measured in aortas, internal pudendal arteries, and penises.

  • Liver, thoracic aorta including the perivascular adipose tissue PVATepidydimal fat pads, retroperitoneal fat pads, intestine with mesenteric artery and PVAT were isolated.

  • High-fat diet induces obesity in adult mice but fails to develop pre-penile and penile vascular dysfunction.

Diet but not gender or genotype altered the composition of gut microbiota. Article type Paper. In conclusion, we show evidence that the genetic background or inbreeding can affect mitochondrial functions in oocytes and may influence the impact of HFD on oocyte quality. LD distribution was strain-dependent. Negative-RT control samples missing reverse transcriptase were included. Cell —

Statistical analysis. Body mass index, surgery, and risk of venous thromboembolism in middle-aged women: a cohort study. In such cases, it seems acceptable to use SCD, which is also used in non-diet high fat diet mice obesity articles studies to provide animals without diet-derived pathologies. It is well known that dietary FAs can influence the level of obesity [ 7 ]. For example, in a week HFD study we identified cardiomyocyte hypertrophy, unsuccessful metabolic adaptations, and lipid droplet accumulation [ 16 ]. Therefore, we speculate that HON may prevent obesity and related complications by producing SCFAs through posterior intestinal fermentation, and that sex is an important factor for different outcomes.

Metabolic Mechanisms and Potential Therapies of Diabetic Cardiac Complications

Journal of visualized Experiments 1—6. For example, cardiac tissue often responds to HFD by increasing its carbohydrate utilizing proteins to extract as much energy from glucose as possible [ 1618 ]. At month 8 and 16, compared with normal mice, in obese mice we observed no change under basal condition, but a reduction of heart inotropic response to dobutamine. Criollo, C.

Download citation. Previous studies have confirmed that HON can improve diet-induced liver lipid metabolism in obese mice 37 Chen H, Jiang W. Therefore, it cannot be ignored that the role of lbesity microbiota in the process of HON acting on the host. Liu, F. On the other side, although the pair-feeding method limits the amount of diet to which animals will have access to, there are cases in which pair-fed diets can achieve different weight gain outcomes, something that has been attributed to the differences in macronutrient composition [ 32 ]. Non-absorbable apple procyanidins prevent obesity associated with gut microbial and metabolomic changes.

Ahn TG, et al. Nicholson, A. Furthermore, inbreeding increases the risk of genetic drift and persistent undiscovered mutations, which may confound responses to experimental factors Received : 15 January Spearow, J. Behav Brain Res 37—

References

Analysis of the mouse gut microbiome using full-length 16s rRNA amplicon sequencing. Yamashita H. Vinegar reduces postprandial hyperglycaemia in patients with type II diabetes when added to a high, but not to a low, glycaemic index meal. Here, the aggregated LDs in B6 mice were also noticed in the control oocytes, at a lower volume, showing that this could be a strain effect and not only induced by diet. Curzon G.

References 1. Weekly food intake, weight gain, and body-fat percentage were measured. Different forms of normal black arrows and abnormal white arrows mitochondrial structures jigh be observed as classified in Supplementary Fig. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. However, the health benefits of Nipa vinegar, especially its anti-obesity effects, have not been evaluated previously. However, these effects were not seen in mice on the Ch diet.

Values in soleus muscle kbesity normalized to those for 18S. Ann NY Acad Sci — Additionally, our data clearly show that the roundness of the mitochondria was highest in Swiss control oocytes and significantly lower in B6 control oocytes, and was further reduced by HFD in both strains. Supplementary information. Grundy SM. Ahmad, D. Jump to site search.

In this work, mice were fed a high-fat diet for 33 weeks. Wilding, M. About this article. This parameter is linked to mitochondrial dysfunction and oxidative stress. This was associated with contrasting responses to HFD-induced metabolic stress. All antagonists were i. Ann NY Acad Sci —

In addition, success rates following assisted reproductive treatments are usually lower as compared to normal body mass index BMI cohorts 34. Fresh-frozen sections of soleus and gastrocnemius muscles in mice at 14 weeks of age of each group were incubated in 0. Fetterman, J. Genome Biol.

The liver of HFD mice is negatively affected in a number of ways muce 21]. Lorenz JN, Robbins J Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse. In the HFD group they identified functional pathology, but only after dobutamine pharmacological stress [ 18 ]. Mandarim-de-Lacerda CA Stereological tools in biomedical research. Kaji, N. Pharmacol Rep.

We hypothesized that the mouse genetic background can influence the impact of high fat diet HFD -induced obesity on oocyte quality. The insulin resistance of obese mice has consistently been determined to be related to the down-regulation of adipose GLUT4 and the overexpression of hepatic GLUT2, suggesting that the dysregulation of glucose homeostasis and increased hepatic glucose output, respectively, play a role in the development of this condition Wu, L. Results 5-HT inhibits weight gain and adiposity of mice fed a high fat diet Mice were fed a chow Ch diet or a high fat F diet and injected i. In contrast, 5-HT did not affect food intake and rectal temperature in mice on either diet Fig 3B and 3C.

On the other hand, Swiss HFD oocytes clearly exhibited a significantly higher expression of genes related to Redox regulation compared to Swiss controls. Blood samples were collected from their hearts by cardiac puncture and tested for glucose levels using a glucose metre. Physiol Rev — Both strains fed 12 weeks of HFD-developed obese phenotypes. Something went wrong. Wu, L.

As the research community identifies the most human-like HFD model the strength of using this model for preclinical protocols can only become better. Krishna et al. Further reading Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring Darren J. The activity of coagulation factors was determined using deficient plasma shorter coagulation time means higher activity on a KC4 Delta Amelung Coagulometer. The American journal of physiology R—

Mice obesity articles droplets were clustered in large aggregates in B6 but were finely scattered in the Swiss ooplasm. On the other hand, Swiss HFD oocytes clearly exhibited a significantly higher expression of genes related to Redox regulation compared to Swiss controls. Recent data suggest that mitochondrial dysfunction may affect UPR signaling in oocytes and embryos following short term in vitro exposure to lipotoxic conditions Odom, M. Mitochondrial roundness and ER swelling indices were calculated and compared. The impact of obesity on oocytes: evidence for lipotoxicity mechanisms.

  • This finding is in line with previous studies which focussed especially on the effects of the content of fibre in NFD

  • Bigger is not always better: the effect of obesity on sexual satisfaction and behavior of adult men in the United States. Overweight and obesity epidemic in developing countries: A problem with diet, physical activity, or socioeconomic status?

  • To study the development of obesity and its risk factors, researchers use diet-induced obesity animal models, since these models reproduce with greater reliability human obesity in comparison with genetic models [7].

  • Densitometric analysis and protein semi-quantification were performed using ImageJ software [26]. Nevertheless, in obese mice we did not see consistent decrease in heart rate when compared with normal mice data not shown.

  • Bonekey Reports 5 Introduction Obesity and related metabolic diseases, which are caused by a high-fat diet HFD and sedentary lifestyle, have been increasing with the improvements in standard of living and the changing lifestyle and have become an urgent public health problem 1.

  • Exact P values are also shown. Data Availability: All relevant data are within the paper.

Several of the responses from the board addressed this issue directly and the answer seems to be that very high fat diets produce a more exaggerated metabolic response than high-fat diets, but the difference is relatively small. High fat diet mice obesity articles clinical and experimental — Previously, it has been shown that senescence-accelerated prone SAMP8 mice fed with high-fat diet underwent a reduction in artery contraction stimulated by phenylephrine, and postulated it as an adaptive mechanism of aged mice to obesity [30]. Compared to animals fed the regular diet, animals fed with the high-fat diet for eight months presented overweight, hyperglycaemia, hyperinsulinemia, hypercholesterolemia Table 2and insulin resistance Figure 1. These methods to model human T2DM have their benefits and their detractions.

The consumption of a high-fat diet leads to an increase in the uptake of fatty acids and lipogenesis aft 1933 ], resulting in adipocytes hyperplasia [ 22061 ] and hypertrophy [ 220283561 ]. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Belkaid Y, Hand T. Light microscopy features of cardiac structure of normal and obese mice. As discussed, which mouse strain to use is also highly important to consider when designing a HFD protocol. Xia, N.

Articlws of human visceral obesity: an update. A HFD can induce obesity and associated complications in mice, such as excessive fat accumulation, dyslipidemia, inflammation, and increased insulin resistance Additionally, when young, speed in weight gain is also greater because elderly animals can adapt metabolically to the increase in adiposity; also, less inflammation is observed in these animals, which causes less glycemic and hepatic alterations [ 1 ].

  • Eventually the pancreas falters and hyperinsulinemia is followed by hypoinsulinemia.

  • Article Google Scholar. Energy expenditure, defined as oxygen consumption VO 2 and carbon dioxide production VCO 2 were measured during a period of 24 h from hours at room temperature.

  • Obesity induced by a pair-fed high fat sucrose diet: methylation and expression pattern of genes related to energy homeostasis.

  • Acknowledgements W.

Mull, T. Effects of carbohydrate feeding on blood coagulation, fibrinolysis and platelet adhesiveness — relations to serum lipids and lipoproteins. Shankar, N. Araujo, H. The presentation of such a large and highly important body of work is daunting.

The aim of this work was to characterize the long-term effects of high-fat diet-induced obesity on the mice cardiovascular system, in order to make available a new animal model for diabetic cardiomyopathy. Thus, the arterial pressure pattern seen in long-term high-fat diet-induced obese mice might be dief by a deficiency in vasoconstriction resistance and the activation of the sympathetic nervous system secondary to insulin-resistance [33]. Examples of knowledge and therapies which have progressed from basic knowledge to preclinical trials in mouse models are numerous [ 2 ] and some examples are reviewed in [ 3 — 5 ]. This can lead to disruption of normal cellular processes and then also to frank lipotoxicity where the excessive lipid molecules damage cellular molecules. DeMartino et al. Use of high-fat diets to study rodent obesity as a model of human obesity. Consent for publication Not applicable.

FEBS J. As peripheral 5-HT is thought to be unable to pass the blood-brain nigh, 5-HT likely had an independent mechanism affecting obesity in the periphery, and not through mce central nervous system involvement [ 34 ]. Bhurosy T, Jeewon R. This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Interestingly, the increase in MMP at the final stage of IVM in bovine oocytes due to lipotoxicity and oxidative stress has been shown to be temporary, and was followed by a subsequent reduction in MMP uncoupling during early cleavage stages 24 Mice on the F diet gained weight until 10 weeks of age with or without the peripheral 5-HT treatment, though 5-HT inhibited their body weight gain after 13 weeks of age.

Among these fermented foods, vinegar, an acidic food seasoning, has recently received substantial attention because it was shown to exhibit multiple bioactivities, including anti-hypercholesterolaemia, anti-hyperglycaemia, anti-hypertension, anti-microbial, anti-thrombotic and even anti-cancer effects 6. Obesity and reproductive function. This aggregation was persistent even after 8w of subsequent diet normalization.

N Engl J Med. Metabolic endotoxemia initiates obesity and insulin resistance. The time to the formation of a clot was recorded 2223 Statistical analysis was performed with GraphPad Prism 7. The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats.

  • Using acute insulin challenge protocols described below, individual, specific tissues can be analyzed for their level of insulin resistance.

  • Discussion This study aimed to investigate mitochondrial dysfunction in oocytes at the structural, functional and molecular level in response to HFD-induced obesity.

  • Although a few previous studies have addressed the difference of the diets on adiposity and inflammation 418no study has directly compared the effects of the diets on vascular function or coagulation.

  • Figure 1.

  • Figure 3.

Glucose Sigma was administered i. Recent studies illustrated that accumulation of damaged mitochondria in obesity-exposed oocytes and their transmission to next generations is due to defective mitophagy 26 Uncoupling occurs particularly in mitochondria that suffer most from high ROS accumulation, which may result in a heterogeneous population of hyperactive and inactive mitochondria within the same oocyte. Maternal obesity and pregnancy outcome: a study ofpregnancies in London.

Comments By submitting a comment you agree to abide by our Terms and Community Guidelines. Biol Psychiatry — Fermented foods, especially vinegars produced from different crops or fruits, are arrticles worldwide to obtain various health benefits, including weight regulation. In order to identify the target tissues of the effect of 5-HT on energy metabolism, we focused on skeletal muscle, and especially the slow muscle fiber type, which has been shown to principally metabolize fatty acids by oxidative means. Odom, M. The prevalence of obesity and metabolic syndrome is increasing and is currently affecting millions of women in reproductive age worldwide.

Glucose intolerance. Yandell, K. SCD is a low-cost and in the most laboratories an easily accessible diet type, which is also used in diet-unrelated studies.

Han K, et al. Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Fruit vinegars, such as pineapple vinegar, have been identified as good sources of antioxidants and compounds with anti-inflammatory effects 6. Diet-induced maternal obesity alters ovarian morphology and gene expression in the adult mouse offspring.

Front Microbiol. Obesity Silver Spring 15— Figure 7. Adipose tissue pathology is at the forefront of HFD investigations and the subsequent pathologies.

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