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Anti tb drugs causing hypothyroidism treatment – The function of the thyroid gland in patients with multi-drug resistant tuberculosis

TSH testing can be challenging in resource-limited settings due to limited availability.

Ethan Walker
Monday, February 27, 2017
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  • Yaqoob A Subclinical hypothyroidism and its consequences. In 30 patients with multidrug resistant tuberculosis, echostructure of thyroid was studied by ultrasound imaging method.

  • The study also did not measure the prevalence of iodine deficiency, although it should be noted that India is among those countries where iodine intake tends to be adequate[ 37 ]. Safety implications of combined antiretroviral and anti-tuberculosis drugs.

  • Accepted : 04 August

Background

It is likely that testing at more regular intervals and throughout the entire length of MDR-TB treatment would increase the time to detection of hypothyroidism. Yes, ethionamide and PAS are both known to cause hypothyroidism particularly the combination and patients may be followed with TSHs. Aug 08

Any patient anti tb drugs causing hypothyroidism treatment required immediate treatment was initiated on an empiric treatment regimen consisting of pyrazinamide, capreomycin, moxifloxacin, ethionamide, cycloserine, and PAS while awaiting the DST result; treatment was then either individualized once DST results became available, or the empiric regimen continued for culture-negative patients with a strong suspicion of drug-resistant TB based on TB treatment history. Discussion 5. Serological Testing Serologic TSH levels were obtained at baseline, at end of 3 and 6 months of anti- tuberculosis treatment using an ultrasensitive sandwich chemi-luminesent-immunologic assay at a private laboratory in Bangalore accredited by the College of American Pathologist and National Accreditation Board for Testing Calibration. J Tuberc Res. PLOS Med 9 8 : e Future studies are needed to find out the proportion of MDR-TB patients developing hypothyroidism during continuous phase as well, as susceptibility for hypothyroidism may continue beyond IP. Undiagnosed hypothyroidism has serious potential sequelae to MDR-TB patients and increases the risk for additional physical and mental health problems.

Chest 1 : All 37 patients in whom hypothyroidism was detected were asymptomatic. Munivenkatappa S 1. Benvenga S.

  • BiosciAbstracts Biosci Abstracts Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences. Discussion: Drug-induced hypothyroidism is an infrequent side effect of tuberculosis therapy, and only a few cases of Rifampicin RFP induced hypothyroidism have been reported so far.

  • Kekkaku76 1001 Oct

  • Patient characteristics, anti-tuberculosis drugs prescribed, and TSH values were obtained from the PMDT register, treatment cards and laboratory reports. It is likely that testing at more regular intervals and throughout the entire length of MDR-TB treatment would increase the time to detection of hypothyroidism.

  • Figure 1.

  • Materials and Methods 2. Patients are required to take a large number of medicines for treating both diseases and additionally, for managing AEs.

Patient characteristics were summarized using descriptive statistics. International Journal of Tuberculosis hypothyroidiem Lung Diseases, 16, Cited by: 17 articles PMID: External link. Sellmeyer DE, Grunfeld C Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome. Click through the PLOS taxonomy to find articles in your field.

These drugs can cause hypothyroidism by inhibiting thyroid hormone synthesis through a mechanism of iodine organification inhibition[ 1516 ]. Currently posted Source Cancel. Related Documents:. It is possible that some these patients may have suffered from hypothyroidism, thus underestimating incidence. To compensate for hypothyroidism, patients with tuberculosis were prescribed L-thyroxine for 3 months or more. View Article Google Scholar 6.

Two cases of hypothyroidism induced by tuberculosis drug

Multidrug-resistant tuberculosis MDR TB remains a health problem for many countries in the world [ 12 ]. Int J Tuberc Lung Dis 16 4 : Article PubMed Google Scholar 2. Matveyeva View author publications. She had been treated for her osteoarticular tuberculosis during the past 12 months with a quadritherapy antituberculous regimen.

Eur Respir J 38 3 : PLOS Med 9 8 : e Patient druts, anti-tuberculosis drugs prescribed, and TSH values were obtained from the PMDT register, treatment cards and laboratory reports. Skaggs, Beth ; Pinto, Isabel ; You can also search for this author in PubMed Google Scholar. Ann Intern Med 12 :

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Front Endocrinol Lausanne, 22 Dec Patients are required to take a large number of medicines for treating both diseases and additionally, for managing AEs. View Article Google Scholar 4. Twenty-three of these Silva, G. In our setting, we managed to prevent overt hypothyroidism by detecting it early and treating it promptly. PAS and ethionamide are known to cause hypothyroidism [4].

Excluding those that had developed hypothyroidism by 3 months, were erugs for TSH testing at 6 causing hypothyroidism treatment. We performed bi- and multi-variate analyses to assess risk factors associated with the occurrence of hypothyroidism. Methods Study design The study was a prospective, observational cohort study using routine clinical and laboratory data. Archives of Endocrinology and Metabolism, 59, Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Int J Tuberc Lung Dis 16 4 :

  • Monitoring and correction of thyroid function during antituberculosis chemotherapy was suggested. The Lancet.

  • PAS and ethionamide are known to cause hypothyroidism [4].

  • Pubmed Central ID:. We performed bi- and multi-variate analyses to assess risk factors associated with the occurrence of hypothyroidism.

Of tested, 31 additional patients developed cauisng between 3 and 6 months. The mechanism of hypothyroidism due to second-line anti-TB drugs is clear and it is both treatable and reversible upon discontinuation of the offending drug [ 1516 ]. Share and Cite:. We assume that the increased rate is due to longer exposure of the cohort to 2 nd line drugs and a greater proportion of patients receiving both PAS and ethionamide. Present study aims to identify the effects of antituberculous treatment on thyroid profile in new smear positive pulmonary tuberculosis cases.

Conclusions Thus, patients with MRD TB anti tb drugs causing hypothyroidism treatment ethionamide and PAS are at increased risk for hypothyroidism and goiter, and therefore require monitoring of thyroid function at all stages of antituberculosis chemotherapy for its timely correction. Indices of thyroid function: plasma levels of free thyroxin, thyroid stimulating hormone were studied before chemotherapy initiated, at the end of intensive phase and after the treatment finished. We followed euthyroidic persons undergoing treatment for multidrug resistant tuberculosis MDR-TB in the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Aug 08 Afr J Lab Med. Those not willing to provide written informed consent or found suffering from hypothyroidism during pre-treatment evaluation were excluded.

1. Introduction

PLOS Med 9 8 : e Search articles by 'Tyson Volkmann'. High rate of hypothyroidism in multidrug-resistant tuberculosis patients co-infected with HIV in Mumbai, India.

Copyright notice. Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark. Andries, A. Int J Tuberc Lung Dis 16 1 : Author information Copyright and License information Disclaimer. Cited by: 1 article PMID:

Vineet K. Hypothyroidism due to ethionamide. Age, gender, CD4 counts and stavudine-based ART were not associated with the occurrence of hypothyroidism in multivariate models. Footnotes Conflict of Interest No conflicts declared. Learn More.

BiosciAbstracts

The number of people being initiated on treatment for multidrug-resistant tuberculosis MDR-TB almost doubled between and as a result of steady annual increases in 12 of 27 countries having a high MDR-TB burden. Naik B 3. In rare cases, hypothyroidism can manifest severely as cardiac disease and development of a pericardial effusion[ 18 ]. Smart citations by scite.

  • Sharada7 Sudhendra Kulkarni1 Vineet K.

  • New Delhi. Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia.

  • Routine TSH testing should be considered for all patients receiving anti-tuberculosis treatment for MDR tuberculosis, especially those receiving regimens containing PAS and ethionamide or antiretrovirals.

  • Endocr Rev 17 5 : Discussion Hypothyroidism was recorded in the majority

  • Rifampin-induced hypothyroidism without underlying thyroid disease. Hypothyroidism is a common AE associated with ethionamide, p-aminosalicylic acid PASand stavudine.

Search articles by 'Manchenahalli A Sharada'. Patient characteristics were summarized using descriptive statistics. Table 1 Demographic and treatment characteristics of patients receiving antituberculosis drug treatment for multidrug-resistant tuberculosis by thyroid stimulating hormone testing—Karnataka, India, October through January The second-line anti-TB drugs associated with hypothyroidism include ethionamide, prothionamide, and PAS[ 2414 ].

Figure 1. Somashekar Munivenkatappa: moc. Between October and Marchpatients were enrolled, 69 of whom were included. Jayachamarajapura S. J Public Health Biol Sciences 1 2 : PloS ONE 4 9 : e

Anti-tuberculosis drug induced hypothyroidism

N Engl J Med 26 : Under PMDT, serologic testing for thyroid-stimulating hormone TSHa biomarker for thyroid functioning, is conducted only amongst MDR-TB patients who passively report experiencing signs and symptoms of hypothyroidism. J Pharmacol Pharmacother. All Rights Reserved.

  • BiosciAbstracts Biosci Abstracts Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences. Introduction The number of people being initiated on treatment for multidrug-resistant tuberculosis MDR-TB almost doubled between and as a result of steady annual increases in 12 of 27 countries having a high MDR-TB burden.

  • Search articles by 'Vineet K Chadha'. Results Between October and Marchpatients were enrolled, 69 of whom were included.

  • PLoS One. Until that happens, we need to reduce as much as possible the frequency of serious adverse events in MDR-TB patients with or without HIV co-infection by systematically screening to detect any adverse events early, including hypothyroidism.

TSH testing can be challenging in resource-limited settings due to limited availability. Patients with MDRTB taking ethionamide and PAS are at druugs risk for hypothyroidism and goiter, and therefore require monitoring of thyroid function at all stages of antituberculosis chemotherapy for its timely correction. In our study, lower CD4 cell counts were associated with hypothyroidism in bivariate analysis, which may be a result of HIV infection itself being associated with thyroid dysfunction. J Pharmacol Pharmacother. Supporting Files:.

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PAS and ethionamide are known to cause hypothyroidism [4]. Vineet K. PloS One. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Thus, we conducted a prospective study to find the proportion of cases that develop hypothyroidism during intensive phase of MDR-TB treatment, using routine serological TSH testing. A limitation of the present study was that TSH testing was performed only at the third and sixth months of treatment.

Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Even mild or subclinical hypothyroidism should not be overlooked as it may increase the risk of co-morbidities such as depression[ 32 ]. A limitation of the present study was that TSH testing was performed only at the third and sixth months of treatment. Conclusion Acknowledgments Footnotes References. Hypothyroidism was recorded in the majority

The functional state of the thyroid gland was assessed by the results of the study of the thyroid echostructure causing hypothyroidism treatment the determination of serum levels of free thyroxine T4 and the thyroid-stimulating hormone of the pituitary TSH before the start of therapy, as well as at the end of the intensive phase and at the end of treatment. Even mild or subclinical hypothyroidism should not be overlooked as it may increase the risk of co-morbidities such as depression[ 32 ]. The Lancet, Sharada7 Sudhendra Kulkarni1 Vineet K. Patients found suffering from hypothyroidism were provided free treatment with levothyroxine according to international guidelines [ 9 ].

Publication types

View Article Google Scholar. Out of 69 patients analyzed as of March37 Clin Infect Dis 37 4 :

  • PubMed: Figure 1.

  • Clinical characteristics of these patients are presented in Table 1.

  • Download PDF.

  • Matveyeva, S.

Abstract We followed euthyroidic persons undergoing treatment for multidrug resistant tuberculosis MDR-TB hypothuroidism the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Yaqoob A Subclinical hypothyroidism and its consequences. Matveyeva, S. Research Open Access Published: 16 August The function of the thyroid gland in patients with multi-drug resistant tuberculosis S. Rifampicin would be the most incremental in this condition. Anti-retroviral drugs stavudine, didanosine, and protease inhibitors used for treatment of HIV can also cause hypothyroidism [ 5 ]. Select one

Similarly sex was previously found to be associated with hypothyroidism in HIV-infected patients but we found no such association in our Mumbai cohort causint drugs causing patients on treatment[ 21 ]. Searchable abstracts of presentations at key conferences in endocrinology. Some patients initially enrolled in the program were treated for a duration of 18 months following the WHO guidelines at that time[ 4 ]. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. It is possible that some these patients may have suffered from hypothyroidism, thus underestimating incidence. No factors were found to be associated with the occurrence of hypothyroidism in multivariate models Table 2.

Materials and Methods 3. Thus, we conducted a prospective study to find the proportion of cases that develop hypothyroidism during intensive phase of MDR-TB treatment, using routine serological TSH testing. Routine TSH testing should be considered for all patients receiving anti-tuberculosis treatment for MDR tuberculosis, especially those receiving regimens containing PAS and ethionamide or antiretrovirals.

Lancet Infect Dis Anti-retroviral drugs stavudine, didanosine, and protease inhibitors used for treatment of HIV can also cause hypothyroidism [5]. Eur Respir J 38 3 : Recent Activity. Author information Copyright and License information Disclaimer.

Download citation. Undiagnosed hypothyroidism has serious potential sequelae to MDR-TB patients and increases the risk for additional physical and mental health problems. She had been treated for her osteoarticular tuberculosis during the past 12 months with a quadritherapy antituberculous regimen. Browse Subject Areas? Collection s :.

1. Introduction

Thyroid, 22, A limitation of the present study was that TSH testing was performed only at the third and sixth months of treatment. Operational research within a Global Fund supported tuberculosis project in India: why, how and its contribution towards change in policy and practice.

  • Contact us.

  • A systematic review and meta-analysis.

  • Anti-retroviral drugs stavudine, didanosine, and protease inhibitors used for treatment of HIV can also cause hypothyroidism [5].

  • TSH testing can be challenging in resource-limited settings due to limited availability. All Rights Reserved.

  • Int J Tuberc Lung Dis 16 9 :

Select one Matveyeva View author publications. PAS and ethionamide are known to cause hypothyroidism [ 4 ]. Int J Tuberc Lung Dis 16 11 : All 37 patients in whom hypothyroidism was detected were asymptomatic. The patient may have mild symptoms usually slight fatigue or none at all. Thyroid, 22,

Jayaprakash KR. Figure 1. And those patients with significant hypothyroid need to started on thyroid supplements. Annals of Internal Medicine, Collection s :.

High rate of hypothyroidism in multidrug-resistant tuberculosis patients co-infected with HIV in Mumbai, India. Cited by: 0 articles PMID: Since TSH was not systematically treatment in all the MDR-TB patients and had to be paid for by patients, the true rate of hypothyroidism is likely to be very much underestimated. Second-line anti-TB drugs are more likely to cause adverse events AE than the first-line anti-tuberculosis drugs used in drug-sensitive TB treatment[ 21213 ].

  • Serological Testing Serologic TSH levels were obtained at baseline, at end of 3 and 6 months of anti- tuberculosis treatment using an ultrasensitive sandwich chemi-luminesent-immunologic assay at a private laboratory in Bangalore accredited by the College of American Pathologist and National Accreditation Board for Testing Calibration.

  • Serological Testing Serologic TSH levels were obtained at baseline, at end of 3 and 6 months of anti- tuberculosis treatment using an ultrasensitive sandwich chemi-luminesent-immunologic assay at a private laboratory in Bangalore accredited by the College of American Pathologist and National Accreditation Board for Testing Calibration.

  • Cancel Continue. When patients had both pulmonary and extrapulmonary TB, we classified them as extrapulmonary TB for the modeling.

  • A limitation of the present study was that TSH testing was performed only at the third and sixth months of treatment. Author Contributions Conceived and designed the experiments: PI.

  • Moonan 5.

Excluding those that had developed hypothyroidism by 3 months, were eligible for TSH testing at 6 months. Ethionamide-induced hypothyroidism. Another four patients 4. Journals Menu. Conceived and designed the experiments: PI. Acknowledgements None declared.

Thyroid function in pulmonary tuberculosis. Thanks to those who posted here and made this information available to others visiting the site. Corresponding author. Current scenario of diabetes in India.

View Article Google Scholar Ongoing efforts to find a better, more efficacious and less toxic second-line TB regimen requiring considerably shorter treatment duration should be the priority of the TB community. Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark. Competing interests: The authors have declared that no competing interests exist. Please review our privacy policy.

All patients should receive serological TSH monitoring during MDR-TB treatment to detect crugs cases of hypothyroidism, which if not treated may lead to poor quality of life, and unfavourable outcomes including death and loss to follow-up. Table 1. Clin Infect Dis 51 1 : Int J Tuberc Lung Dis 16 4 : According to the literature, thyroid dysfunction may have infectious, hemorrhagic, or neoplastic etiologies[ 29 - 31 ].

Of them, 8 were not tested. The time-to-hypothyroidism was measured using Kaplan-Meier analysis data were censored by 30 th March Another four patients 4. Euthyroid sick syndrome. During treatment with tuberculosis drug, he had never received thyroid replacement therapy. Toggle navigation. Author manuscript; available in PMC Sep 1.

Treatment for patients having MDR strains requires use of acusing anti-TB drugs and a treatment duration of at least hypothyroidism treatment months[ 24 - 6 ]. Hypothyroidism is separated into either overt or subclinical disease. Patients found suffering from hypothyroidism were provided free treatment with levothyroxine according to international guidelines [ 9 ]. Thus, we conducted a prospective study to find the proportion of cases that develop hypothyroidism during intensive phase of MDR-TB treatment, using routine serological TSH testing. Ann Clin Biochem. The study was conducted in accordance with international standard ethical standards and issued using appropriate protocols and obtaining informed consent from all patients included in the study.

Under PMDT, serologic testing for thyroid-stimulating hormone TSHa biomarker for thyroid functioning, is conducted only amongst MDR-TB patients who passively report experiencing signs and symptoms of hypothyroidism. Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia. Another four patients 4. Journals Menu. Search articles by 'Manchenahalli A Sharada'.

Matveyeva View author publications. Materials and Methods 2. Jan 22 Those not willing to provide written informed consent or found suffering from hypothyroidism during pre-treatment evaluation were excluded.

Discussion Hypothyroidism was recorded in the majority Treatment for patients having MDR strains treatment use of second-line anti-TB drugs and a treatment duration of at least 20 months[ 24 - 6 ]. Similarly sex was previously found to be associated with hypothyroidism in HIV-infected patients but we found no such association in our Mumbai cohort of co-infected patients on treatment[ 21 ]. Search articles by 'Jayachamarajapura S Akshatha'. Sharma SK, Mohan A Multidrug-resistance tuberculosis: a menace that threatens to destabilize tuberculosis control. Search articles by 'Singarajipura Anil'.

Intern Med J49 301 Mar Garber, J. Int J Tuberc Lung Dis 16 4 :

  • Download: PPT.

  • Chadha 7Patrick K. Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

  • The mean level of TSH increased at the end of the intensive care phase from 1.

  • The Lancet. The aim of the study is to define the side effects of second line drugs used in the treatment of MDR TB on thyroid function.

  • Volkmann T 4. J Tuberc Res.

When patients required hospitalization, MSF collaborated with private and government hospitals; Sewri TB Hospital was the only cauisng hospital in Mumbai having hospital wards designed to accommodate tuberculosis patients. We followed euthyroidic persons undergoing treatment for multidrug resistant tuberculosis MDR-TB in the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Lee S, Farwell AP. Chadha7 and Patrick K.

Int J Tuberc Lung Dis 16 1 : Excluding those that had developed hypothyroidism by 3 months, were eligible for TSH testing at 6 months. Ramachandran A, Snehalatha C. View author publications. The obtained data allows making a conclusion about the suppressive effect of anti-tuberculosis drugs on the hormonal function of the thyroid gland of multidrug-resistant tuberculosis patients.

Figure 2. All Rights Reserved. Sagili6 Jayachamarajapura S. Once the WHO guidelines were updated inthe treatment duration was adjusted accordingly to a minimum of 20 months[ 6 ].

Compr Physiol. Early hypothyroidism screening was recommanded in treated tuberculosis causlng avoid severe and complicated forms especially in the elderly. Of the 47 patients excluded from the study Figure 118 of them did not have two TSH measurements i. Andries, A. Lancet Research Open Access Published: 16 August The function of the thyroid gland in patients with multi-drug resistant tuberculosis S. DOI:

Of them, 33 were not tested due to for various programmatic reasons. AIDS 14 8 : — Clin Infect Dis 51 1 : Sagili 6Jayachamarajapura S.

Note: Javascript is disabled or is not supported by your browser. Modongo, Hyoothyroidism. Tuberculosis and patient gender: An analysis and its implications in tuberculosis control. Under PMDT, serologic testing for thyroid-stimulating hormone TSHa biomarker for thyroid functioning, is conducted only amongst MDR-TB patients who passively report experiencing signs and symptoms of hypothyroidism.

BMC Infect Dis 13 1 : View Article Google Scholar 7. Search articles by 'Tyson Volkmann'. Ann Intern Med Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark.

  • Serologic TSH levels were obtained at causign, at end of 3 and 6 months of anti-tuberculosis treatment using an ultrasensitive sandwich chemi-luminesent-immunologic assay at a private laboratory in Bangalore accredited by the College of American Pathologist and National Accreditation Board for Testing Calibration. Subclinical dysfunction of TSH level was diagnosed at the significance of more than 4.

  • Demographic and treatment characteristics of patients receiving antituberculosis drug treatment for multidrug-resistant tuberculosis by thyroid stimulating hormone testing—Karnataka, India, October through January

  • J Tuberc Res.

  • Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark.

  • Matveyeva, S.

Table 1. References 1. Of them, 33 were not tested due to for various programmatic reasons. Disclaimer The findings and conclusions in this hypothyroodism are those of the authors and do not necessarily reflect the official position of the U. Out of 69 patients analyzed as of March37 Excluding those that had developed hypothyroidism by 3 months, were eligible for TSH testing at 6 months. PloS One.

Thus, patients with MRD TB taking ethionamide and PAS are at increased risk for hypothyroidism and goiter, and therefore require monitoring of thyroid function at all stages of antituberculosis chemotherapy for its timely correction. Lyon, France 18 May - 21 May Competing interests The authors declare that they have no competing interests. PAS and ethionamide are known to cause hypothyroidism [ 4 ]. Hypothyroidism due to ethionamide. Observations: Case 1: A year-old male, complaining of asthenia and weight gain.

Results Between October and Marchpatients were enrolled, 69 of whom were included. Any patient who required immediate treatment was initiated on an empiric treatment regimen consisting of pyrazinamide, capreomycin, moxifloxacin, ethionamide, cycloserine, and PAS while awaiting the DST result; treatment was then either individualized once DST results became available, or the empiric regimen continued for culture-negative patients with a strong suspicion of drug-resistant TB based on TB treatment history. Search articles by 'Singarajipura Anil'.

  • Methods Study design The study was a prospective, observational cohort study using routine clinical and laboratory data.

  • Garber, J.

  • Multidrug-resistant tuberculosis MDR TB remains a health problem for many countries in the world [ 12 ].

  • In addition to a potential negative effect on adherence to MDR-TB treatment, untreated depression will also result in suboptimal adherence to antiretroviral treatment[ 33 ]. Of them, 8 were not tested.

Twenty-three of these Akshatha JS 6. Search articles by 'Vineet K Chadha'. Copyright notice. Antiretrovirals and drug-resistant TB drugs have potentially overlapping AEs[ 141920 ].

  • Author manuscript; available in PMC Sep 1.

  • Author Contributions Conceived and designed the experiments: PI.

  • Sick euthyroid was found to have decreasing trend during the course of treatment, and hypothyroidism was found to be increasing trend end of 6 months. The findings and conclusions in this paper are those of the authors and do not necessarily reflect the official position of the U.

  • Antiretrovirals and drug-resistant TB drugs have potentially overlapping AEs[ 141920 ]. Clin Infect Dis 51 1 :

Egyptian Journal of Chest Diseases and Tuberculosis. Age, sex, category of TB pulmonary or extra-pulmonary and stavudine were not associated with antti occurrence of hypothyroidism. Author manuscript; available in PMC Sep 1. The mechanism of hypothyroidism due to second-line anti-TB drugs is clear and it is both treatable and reversible upon discontinuation of the offending drug [ 1516 ]. External link. Chemotherapy42 Suppl ; discussion01 Jan

Yaqoob A Subclinical hypothyroidism and its consequences. Remember me. MDR-TB is defined as tuberculosis that is resistant to isoniazid and rifampicin, the two most effective anti-TB drugs in the first-line regimen[ 24 ]. Ann Clin Biochem. Int J Tuberc Lung Dis 16 9 :

All authors read and approved the final manuscript. Archives of Endocrinology and Metabolism. Int J Tuberc Lung Dis 16 4 :

Those not willing to provide written informed consent or found suffering from hypothyroidism during pre-treatment evaluation were excluded. Improved capacity for MDR-TB case detection has also contributed to the increasing number of cases[ 1 ]. Lancet Keywords Anti-tuberculosis treatment, Hypothyroidism, Thyroid stimulating hormone.

All patients with laboratory- confirmed drug-resistant Hypothyroodism are treated with a standard regimen; this includes an intensive phase consisting of kanamycin, cycloserine, levofloxacin, ethionamide, ethambutol, and pyrazinamide for 6 - 9 months followed by a continuation phase of 18 months with cycloserine, levofloxacin, ethionamide, and ethambutol [2]. BackgroundControl of genital infections remains challenging in most regions. Tuberculosis and patient gender: An analysis and its implications in tuberculosis control. These indicators were selected in accordance with modern generally accepted screening standards for the detection of thyroid function. And those patients with significant hypothyroid need to started on thyroid supplements. Hypothyroidism was recorded in the majority

Matveyeva, O. A thyroid profile that was repeated after the exclusion of tuberculosis drug at end of his treatment showed the decrease in needs of L -thyroxine therapy and the following results: the TSH level was normalized 3. Collection s :.

Under PMDT, serologic testing for thyroid-stimulating hormone Hyopthyroidisma biomarker for thyroid functioning, is conducted only amongst MDR-TB patients who passively report experiencing signs and symptoms of hypothyroidism. A limitation of the present study was that TSH testing was performed only at the third and sixth months of treatment. Share and Cite:. PAS and ethionamide are known to cause hypothyroidism [4]. View Article Google Scholar 7.

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Open in a separate window. Of them, 33 were not tested due to for causnig programmatic reasons. Another four patients 4. The increasing trend towards drug-resistant TB in several high burden countries throughout the world will pose a serious public health threat for future generations[ 1 - 3 ]. TSH testing can be challenging in resource-limited settings due to limited availability.

Int J Tuberc Lung Dis 11 12 : Causjng providers should not wait for clinical symptoms, as this risks compromising treatment adherence. Silva, G. Thus, we conducted a prospective study to find the proportion of cases that develop hypothyroidism during intensive phase of MDR-TB treatment, using routine serological TSH testing.

AIDS 5 6 : The duration of goiter development was in average 8 months range 6—13 months. Competing interests: The authors have declared that no competing interests exist. Euthyroid sick syndrome.

Patients are required to take a large number of medicines for treating both diseases and additionally, for managing AEs. All patients with laboratory- confirmed drug-resistant TB are treated with a standard regimen; this includes an tratment phase consisting of kanamycin, cycloserine, levofloxacin, ethionamide, ethambutol, and pyrazinamide for 6 - 9 months followed by a continuation phase of 18 months with cycloserine, levofloxacin, ethionamide, and ethambutol [2]. Undiagnosed hypothyroidism has serious potential sequelae to MDR-TB patients and increases the risk for additional physical and mental health problems. How to cite item. Under PMDT, serologic testing for thyroid-stimulating hormone TSHa biomarker for thyroid functioning, is conducted only amongst MDR-TB patients who passively report experiencing signs and symptoms of hypothyroidism.

  • Remember me. High rate of hypothyroidism among patients treated for multidrug-resistant tuberculosis in Lesotho.

  • Click through the PLOS taxonomy to find articles in your field. The number of people being initiated on treatment for multidrug-resistant tuberculosis MDR-TB almost doubled between and as a result of steady annual increases in 12 of 27 countries having a high MDR-TB burden.

  • DOI:

  • Antiretrovirals and drug-resistant TB drugs have potentially overlapping AEs[ 141920 ].

  • Searchable abstracts of presentations at key conferences in endocrinology.

  • Of them, 8 were not tested.

Methods Study design The study was a prospective, observational cohort study using routine clinical and laboratory data. A systematic review and meta-analysis. The increasing trend towards drug-resistant TB in several high burden countries throughout the world will pose a serious public health threat for future generations[ 1 - 3 ]. External link. Buggi S 6. Chest 1 :

Prev Next. Chadha7 and Patrick K. Jayachamarajapura S. Informed consent to the patient was not obtained since the data used in the study were routinely collected for treatment monitoring. Efavirenz, amprenavir, lopinavir, and ritonavir were also found to be associated with hypothyroidism[ 22 ].

Lee S, Farwell AP. Two patients 6. Rifampin-induced hypothyroidism without underlying thyroid disease. On the other hand, these operational data reflect the reality of patient care in our setting, which has room for improvement. The mean level of TSH increased at the end of the intensive care phase from 1.

Efavirenz, amprenavir, lopinavir, and ritonavir were also found to be associated with hypothyroidism[ 22 ]. Table 2. Ongoing efforts to find a better, more efficacious and less toxic second-line TB regimen requiring considerably shorter treatment duration should be the priority of the TB community. Cited by: 1 article PMID:

However, there are few d In the event of drug intolerance or severe adverse reactions to kanamycin and cycloserine, paraaminosalicylate sodium Tbb may be used as a substitute drug [ 3 ]. Demographic and treatment characteristics of patients receiving antituberculosis drug treatment for multidrug-resistant tuberculosis by thyroid stimulating hormone testing—Karnataka, India, October through January Of tested, 31 additional patients developed hypothyroidism between 3 and 6 months. Lyon, France 18 May - 21 May Until that happens, we need to reduce as much as possible the frequency of serious adverse events in MDR-TB patients with or without HIV co-infection by systematically screening to detect any adverse events early, including hypothyroidism.

View Article Google Scholar 6. Ann Intern Med View Article Google Scholar 4. Thus, we conducted anti tb drugs causing hypothyroidism treatment prospective study to find the proportion of cases that develop hypothyroidism during intensive phase of MDR-TB treatment, using routine serological TSH testing. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Fifty human immunodeficiency virus negative patients and 20 controls were included.

Volkmann T 4. Ongoing efforts to find a better, more efficacious and less toxic second-line TB regimen requiring considerably shorter treatment duration should be the priority of the TB community. The findings and conclusions in this paper are those of the authors and do not necessarily reflect the official position of the U. Drucker, D.

Endocrine Abstracts. Search all BMC articles Search. Related Documents:. That diagnosis is determined on the basis of the TSH laboratory blood tests.

A systematic review and meta-analysis. Vineet K. Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark. Somashekar Munivenkatappa: moc. Even mild or subclinical hypothyroidism should not be overlooked as it may increase the risk of co-morbidities such as depression[ 32 ]. Future studies are needed to find out the proportion of MDR-TB patients developing hypothyroidism during continuous phase as well, as susceptibility for hypothyroidism may continue beyond IP. Conflict of Interest No conflicts declared.

Discussion Hypothyroidism was recorded hpyothyroidism the majority anti tb drugs causing hypothyroidism treatment Clin Infect Dis 37 4 : Data was recorded in a structured data collection sheet, double entered, validated and analysed using EpiData software EpiData Association, Odense, Denmark. Funding Funders who supported this work. Although stavudine has been found elsewhere to be associated with the occurrence of hypothyroidism[ 21 ], no association was found in this study. If hypothyroidism was present, T3, T4 and thyroid peroxidase autoantibodies were measured, and imaging extended to scintigraphy and repeated ultrasonography.

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