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Hypothyroidism in pregnancy pubmed database – Interventions for clinical and subclinical hypothyroidism in pregnancy

The mean duration of hypothyroidism during pregnancy was High-quality evidence is lacking and large-scale randomised trials are urgently needed in this area.

Ethan Walker
Wednesday, March 1, 2017
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  • Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

  • There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. Publication types Research Support, Non-U.

  • Authors' conclusions: This review found no difference between levothyroxine therapy and a control for treating pregnant euthyroid women with thyroid peroxidase antibodies for the outcome of pre-eclampsia, however a reduction in preterm birth and a trend towards reduced miscarriage with levothyroxine was shown.

  • Adverse pregnancy outcomes included abortions in 7. Most cases had an autoimmune aetiology.

Publication types

Results: The study group accounted for 1. The effectiveness of LT4 on improving maternofetal and long-term offspring outcomes is still not fully elucidated. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. The mean duration of hypothyroidism during pregnancy was

Substances Thyrotropin Thyroxine. Databasr review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. None of the three trials reported on childhood neurodevelopmental delay. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. High-quality evidence is lacking and large-scale randomised trials are urgently needed in this area.

In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. Publication types Research Support, Non-U. Substances Thyrotropin Thyroxine. Supplementary concepts Hypothyroidism, Autoimmune.

In one trial of hypothyroidism in pregnancy pubmed database, levothyroxine therapy to treat pregnant euthyroid normal thyroid function women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Nevertheless, a large percentage of general practitioners, obstetricians and gynecologists perform screening procedures in Iran. This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Substances Selenomethionine Thyroxine. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

MeSH terms

Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. Substances Thyroxine. Results: The study group accounted for 1.

One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. Background: Over the last hypothyroidismm there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Abstract Objective: To evaluate the relationship between subclinical hypothyroidism SCH and the risk of miscarriage before 20 weeks of pregnancy. In one trial of women, levothyroxine therapy to treat pregnant euthyroid normal thyroid function women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0.

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Abstract Background: Thyroid dysfunction during pregnancy is associated with adverse pubmed database for both mother datavase fetus. Main results: We included four RCTs of moderate risk of bias involving women. Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Gov't Review Systematic Review. Publication types Research Support, Non-U. In one trial of women, levothyroxine therapy to treat pregnant euthyroid normal thyroid function women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0.

Summary: Current evidence strengthens the association between SCH with both maternofetal and offspring adverse outcomes. Nevertheless, the effects of SCH during central secondary hypothyroidism causes and the efficacy of its treatment on maternofetal outcomes are not well established. Objectives: To htpothyroidism interventions used in the management of hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. Gov't Review Systematic Review. The importance of sufficient maternal thyroid supply during pregnancy is well known. Although interventional studies have shown a benefit of levothyroxine LT4 treatment on selected pregnancy outcomes, there was no effect on offspring neurodevelopment.

Publication types

All the statistical analyses were performed using Review Manager Revman Version 5. Compared with untreated hypithyroidism women, pregnancy pubmed database women treated with levothyroxine were significantly younger, had a lower Charlson Comorbidity Index score and had lower rates of comorbid type 2 diabetes and migraines. Regardless of the diagnostic criteria used, the miscarriage rate increased as long as a pregnant woman was confirmed to have SCH. Publication types Review.

Most studies have focused on subjects with a mild or subclinical disorder. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. Purpose of review: Subclinical hypothyroidism SCH is a common diagnosis among women of reproductive age. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Supplementary concepts Hypothyroidism, Autoimmune.

Most studies hypothyroidism in pregnancy pubmed database focused on subjects with a mild or subclinical disorder. Thyroxine T4 replacement therapy should reduce thyrotropin TSH concentration to the recently suggested fixed upper limits of 2. In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. The use of antithyroid drug methimazole, propylthiouracil, carbimazole is the first choice for treating overt hyperthyroidism, although they are not free of side effects. Substances Thyrotropin Thyroxine. High-quality evidence is lacking and large-scale randomised trials are urgently needed in this area. Substances Thyroxine.

I 2 index and Q test were used to assess differences in studies. Adverse pregnancy outcomes included abortions in 7. Substances Thyrotropin Thyroxine. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women.

Background: Thyroid dysfunction during pregnancy is associated with adverse outcomes for both mother and fetus. Childhood neurodevelopmental delay was not assessed by any trial included in hypothyroidism in pregnancy pubmed database review. The use of antithyroid drug methimazole, propylthiouracil, carbimazole is the first choice for treating overt hyperthyroidism, although they are not free of side effects. Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. P-value less than 0.

In one pregnaancy of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies pubmed database not shown to reduce pre-eclampsia significantly risk ratio RR 0. Adverse pregnancy outcomes included abortions in 7. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy pretnancy be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Recent findings: Recent observational studies have found a positive association between SCH during pregnancy and adverse maternal, neonatal and offspring outcomes, mainly in thyroid peroxidase autoantibody positive women. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes.

  • Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes.

  • Publication types Research Support, Non-U.

  • In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0.

  • A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

  • The mean duration of hypothyroidism during pregnancy was Recent findings: Recent observational studies have found a positive association between SCH during pregnancy and adverse maternal, neonatal and offspring outcomes, mainly in thyroid peroxidase autoantibody positive women.

  • Supplementary concepts Hypothyroidism, Autoimmune. None of the four trials reported on childhood neurodevelopmental delay.

Gov't Review Systematic Review. Childhood neurodevelopmental delay was not assessed by any trial included in the review. None of the three trials reported on childhood neurodevelopmental delay. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women. Authors' conclusions: Levothyroxine treatment of clinical hypothyroidism in pregnancy is already standard practice given the documented benefits from earlier non-randomised studies. Abstract Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period.

All the statistical analyses were performed using Review Manager Revman Version 5. On the other hand, evidence about the effect of thyroid screening and treatment pregnancy pubmed database thyroid disorders on pregnancy outcomes is still insufficient. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage. Maximum serum TSH level measured was Conclusions: Abortions and premature deliveries occur infrequently in women with severe hypothyroidism.

Most studies have focused on subjects with a mild or subclinical disorder. Adverse pregnancy outcomes included abortions in 7. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes.

  • This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown. This study characterizes pregnant women with hypothyroidism and examines adherence to guidelines during pregnancy.

  • Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Adverse pregnancy outcomes included abortions in 7.

  • Most studies have focused on subjects with a mild or subclinical disorder. Data were collected from the medical records.

Substances Selenomethionine Thyroxine. Authors' conclusions: Levothyroxine treatment of clinical hypothyroidism in pregnancy is already hypothyroidism in pregnancy pubmed database practice given the documented benefits from earlier non-randomised studies. Gov't Review Systematic Review. Maximum serum TSH level measured was In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0.

The funders had no role in study design, data collection hypotthyroidism analysis, decision to publish, pregnancy pubmed database preparation of the manuscript. Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. Results: Finally, 19 eligible studies including 17, pregnant women included for meta-analysis. Abstract Objective: To evaluate the relationship between subclinical hypothyroidism SCH and the risk of miscarriage before 20 weeks of pregnancy. The prevalence of thyroid dysfunction in Iranian pregnant women was Selection criteria: Randomised controlled trials RCTs and quasi-randomised controlled trials that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy with another intervention or placebo. Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy.

Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism in hgpothyroidism and to ascertain the impact of these hypothyroidism in pregnancy pubmed database on important maternal, fetal, neonatal and childhood outcomes. The publication bias of the studies was assessed by forest plot and Begg's test, while the stability of the results was evaluated by sensitivity analysis. The present meta-analysis was conducted to evaluate thyroid dysfunction in Iranian pregnant women.

Overt hyperthyroidism during pregnancy is relatively uncommon but needs prompt treatment due to the increased risk of preterm delivery, congenital malformations, and fetal death. Abstract Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Substances Thyroxine. Conclusions: A large percentage of pregnant women, including many treated with levothyroxine, was not treated in a manner consistent with clinical guidelines. Results: Nine articles satisfying the inclusion criteria were analysed. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

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Objective: To evaluate the relationship between subclinical hypothyroidism SCH and the risk pregbancy miscarriage before 20 weeks of pregnancy. Publication types Research Support, Non-U. Data were collected from the medical records. Among women treated with levothyroxine, Results: The average age was Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. Grant support.

In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk hypothyroidism in pregnancy pubmed database RR 0. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Substances Selenomethionine Thyroxine. The effectiveness of LT4 on improving maternofetal and long-term offspring outcomes is still not fully elucidated. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women.

Maximum serum TSH level measured was There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. Main results: We included four RCTs of moderate risk of bias involving women. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. None of the three trials reported on childhood neurodevelopmental delay.

Substances Thyroxine. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Data were collected from the medical records.

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Purpose of review: Subclinical hypothyroidism Uypothyroidism is a common diagnosis among women of reproductive age. This review discusses the recent evidence on SCH in pregnancy hypothyroidism in pregnancy pubmed database how this evidence is reflected in current clinical care. Authors' conclusions: This review found no difference between levothyroxine therapy and a control for treating pregnant euthyroid women with thyroid peroxidase antibodies for the outcome of pre-eclampsia, however a reduction in preterm birth and a trend towards reduced miscarriage with levothyroxine was shown. None of the four trials reported on childhood neurodevelopmental delay. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

Abstract Background: Over the last decade there has been enhanced awareness of hypothyroidism in pregnancy pubmed database appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. There is a probable low incidence of adverse outcomes from levothyroxine and selenomethionine. Childhood neurodevelopmental delay was not assessed by any trial included in the review. Main results: We included four RCTs of moderate risk of bias involving women. The importance of sufficient maternal thyroid supply during pregnancy is well known. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown.

Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted pubmed database data. There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. None of the three trials reported on childhood neurodevelopmental delay. Substances Selenomethionine Thyroxine. Abstract Purpose of review: Subclinical hypothyroidism SCH is a common diagnosis among women of reproductive age.

Substances

Subclinical hyperthyroidism tends to be hylothyroidism and no pharmacological treatment is usually needed. Conclusions: A large percentage of pregnant women, including many treated with levothyroxine, was not treated in a manner consistent with clinical guidelines. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. The prevalence of hypothyroidism, clinical hypothyroidism, and subclinical hypothyroidism in Iranian pregnant women was respectively estimated to be

Most cases had an autoimmune aetiology. Since treating hypothyroidism in pregnancy pubmed database and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. Substances Selenomethionine Thyroxine. Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis.

Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact datbaase these interventions on important maternal, fetal, neonatal dwtabase childhood outcomes. The aims of the present study were to determine the relative rate of severe thyroid dysfunction among pregnant women with hypothyroidism, identify related factors and analyse the impact on pregnancy outcomes. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Childhood neurodevelopmental delay was not assessed by any trial included in the review. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. An earlier and more individualized diagnostic assessment taking into consideration predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy.

MeSH terms

Substances Selenomethionine Thyroxine. The present meta-analysis was conducted to evaluate thyroid dysfunction in Iranian pregnant women. Results: The pregancy group accounted for 1. Thyroxine T4 replacement therapy should reduce thyrotropin TSH concentration to the recently suggested fixed upper limits of 2. In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0.

Hyporhyroidism findings: Recent observational studies have found a positive association between SCH during pregnancy and adverse maternal, neonatal and offspring outcomes, mainly in thyroid peroxidase autoantibody positive women. Main results: We included four RCTs of moderate risk of bias involving women. Summary: Current evidence strengthens the association between SCH with both maternofetal and offspring adverse outcomes. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care.

Main results: We included three RCTs of moderate risk of bias involving women. This review discusses the recent evidence on SCH in pregnancy hypothyroidism how this evidence is reflected in current hypothryoidism care. The aims of the present study were to determine the relative rate of severe thyroid dysfunction among pregnant women with hypothyroidism, identify related factors and analyse the impact on pregnancy outcomes. Substances Selenomethionine Thyroxine. Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. Authors' conclusions: Levothyroxine treatment of clinical hypothyroidism in pregnancy is already standard practice given the documented benefits from earlier non-randomised studies.

  • In particular, the function of the central nervous system might be impaired, causing low intelligence quotient, and mental retardation. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

  • There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis.

  • Gov't Review Systematic Review.

  • An earlier and more individualized diagnostic assessment taking into consideration predictors pubmed database thyroid dysfunction and major ;ubmed factors for complications could result in better management of SCH during pregnancy. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women.

  • Among women treated with levothyroxine, Compared with untreated pregnant women, pregnant women treated with levothyroxine were significantly younger, had a lower Charlson Comorbidity Index score and had lower rates of comorbid type 2 diabetes and migraines.

Studies comparing the prevalence of miscarriage in pregnant women with SCH with those who were euthyroid were selected. None of the four pybmed reported on childhood neurodevelopmental delay. We identified potential articles from the databases, and articles remained after removing the duplicate and unrelated studies. All the statistical analyses were performed using Review Manager Revman Version 5. On the other hand, evidence about the effect of thyroid screening and treatment of thyroid disorders on pregnancy outcomes is still insufficient.

Most cases had hylothyroidism autoimmune aetiology. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Publication types Research Support, Non-U. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1. The prevalence of anti-thyroperoxidase antibody was estimated to be

A trial of women compared the trace element dataase selenium with placebo and no significant differences were hypothyroidism for either pre-eclampsia RR 1. Selection criteria: Randomised controlled trials RCTs and quasi-randomised controlled trials that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy with another intervention or placebo. The aims of the present study were to determine the relative rate of severe thyroid dysfunction among pregnant women with hypothyroidism, identify related factors and analyse the impact on pregnancy outcomes. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women. Substances Thyrotropin Thyroxine.

Childhood neurodevelopmental delay was not assessed by any trial included in the review. Main results: We included four RCTs of moderate risk of bias involving women. Adverse pregnancy outcomes included abortions in 7. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. Selenomethionine as an intervention in women with thyroid autoantibodies is promising, particularly in reducing postpartum thyroiditis. Authors' conclusions: Levothyroxine treatment of clinical hypothyroidism in pregnancy is already standard practice given the documented benefits from earlier non-randomised studies. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women.

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Publication types Research Support, Non-U. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. Most studies have focused on subjects with a mild or subclinical disorder. The mean duration of hypothyroidism during pregnancy was Maximum serum TSH level measured was A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

Adverse pregnancy outcomes included abortions in 7. Maximum serum TSH level measured was The prevalence of hypothyroidism in pregnancy pubmed database, clinical hypothyroidism, and subclinical hypothyroidism in Iranian pregnant women was respectively estimated to be Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective. Gestational transient hyperthyroidism is a self-limited non-autoimmune form of hyperthyroidism with negative antibody against TSH receptors, that is related to hCG-induced thyroid hormone secretion.

An earlier and more individualized diagnostic assessment taking into pubmef predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy. Most cases had an autoimmune aetiology. Gov't Review Systematic Review. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

Selection criteria: Randomised controlled trials RCTs that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism in pregnancy with another intervention or placebo. An pubmex and more individualized diagnostic assessment taking into consideration predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy. Supplementary concepts Hypothyroidism, Autoimmune. Adverse pregnancy outcomes included abortions in 7. Design: A retrospective case series design was employed. Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

Substances Thyrotropin Thyroxine. One trial of 30 hypothyroid women compared levothyroxine doses, but only reported biochemical outcomes. This review also showed no difference for pregnsncy or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown. Authors' conclusions: Levothyroxine treatment of clinical hypothyroidism in pregnancy is already standard practice given the documented benefits from earlier non-randomised studies. High-quality evidence is lacking and large-scale randomised trials are urgently needed in this area. Publication types Research Support, Non-U. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

Although interventional studies have shown a benefit of levothyroxine LT4 treatment on selected pregnancy outcomes, there was no effect on database neurodevelopment. Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women. Summary: Current evidence strengthens the association between SCH with both maternofetal and offspring adverse outcomes. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Abstract Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes.

Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. On the other hand, evidence about the effect of thyroid screening and treatment of thyroid disorders on pregnancy outcomes is still insufficient. Conclusion: The results of this meta-analysis showed a high prevalence of thyroid disorders, especially hypothyroidism. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

Hypothyroidism causes hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data. Most studies have focused on subjects with a mild or subclinical disorder. In particular, the function of the central nervous system might be impaired, causing low intelligence quotient, and mental retardation. Pregnancy outcomes were compared with those of a control group of euthyroid pregnant women during the same period. Overt and subclinical dysfunctions of the thyroid disease should be treated appropriately in pregnancy, aiming to maintain euthyroidism.

Main results: We included three RCTs of moderate risk of bias involving women. Objective: To evaluate the relationship between subclinical hypothyroidism SCH and the risk of miscarriage before 20 weeks of pregnancy. The prevalence of hyperthyroidism, clinical hyperthyroidism, and subclinical hyperthyroidism in Iranian pregnant women was respectively estimated to be 3.

  • The prevalence of anti-thyroperoxidase antibody was estimated to be Overt and subclinical dysfunctions of the thyroid disease should be treated appropriately in pregnancy, aiming to maintain euthyroidism.

  • Purpose of review: Subclinical hypothyroidism SCH is a common diagnosis among women of reproductive age. Nevertheless, the effects of SCH during pregnancy and the efficacy of its treatment on maternofetal outcomes are not well established.

  • A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1. Gov't Review Systematic Review.

  • Maximum serum TSH level measured was

  • Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes.

Objectives: To identify interventions used in the management hypothyroidism in pregnancy pubmed database hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes. Keywords: Iran; Meta-analysis; Pregnant women; Thyroid dysfunction. Grant support. Subclinical hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed.

  • Conclusions: A large percentage of pregnant women, including many treated with levothyroxine, was not treated in a manner consistent with clinical guidelines. Abstract Purpose: To review the literature on thyroid function and thyroid disorders during pregnancy.

  • Design: A retrospective case series design was employed.

  • Results: Finally, 19 eligible studies including 17, pregnant women included for meta-analysis.

Pregnancy outcomes were compared with those of causes control group of euthyroid pregnant women during the same period. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1. The present meta-analysis was conducted to evaluate thyroid dysfunction in Iranian pregnant women. In particular, the function of the central nervous system might be impaired, causing low intelligence quotient, and mental retardation.

None of the four trials reported on childhood neurodevelopmental delay. The funders had no role in study design, data hypothyroiddism and analysis, decision to publish, or preparation of the manuscript. Publication types Review. The decision to recommend thyroid screening during pregnancy for all women is still under debate, because the positive effects of treatment on pregnancy outcomes must be ensured.

Results: The average age was Gestational transient hyperthyroidism is a databsse non-autoimmune form of hyperthyroidism with negative antibody against TSH receptors, that is related to hCG-induced thyroid hormone secretion. Main results: We included four RCTs of moderate risk of bias involving women. Most cases had an autoimmune aetiology. Overt hyperthyroidism during pregnancy is relatively uncommon but needs prompt treatment due to the increased risk of preterm delivery, congenital malformations, and fetal death.

Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and hypothyroidism in pregnancy pubmed database utilised in hypothyroid women. An earlier and more individualized diagnostic assessment taking into consideration predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy. Maximum serum TSH level measured was Recent findings: Recent observational studies have found a positive association between SCH during pregnancy and adverse maternal, neonatal and offspring outcomes, mainly in thyroid peroxidase autoantibody positive women.

  • Compared with untreated pregnant women, pregnant women treated with levothyroxine were significantly younger, had a lower Charlson Comorbidity Index score and had lower rates of comorbid type 2 diabetes and migraines. Abstract Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes.

  • Conclusions: Abortions and premature deliveries occur infrequently in women with severe hypothyroidism.

  • A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

  • Data were extracted after applying the inclusion and exclusion criteria and qualitative evaluation of the studies. Conclusions: Abortions and premature deliveries occur infrequently in women with severe hypothyroidism.

High-quality evidence is lacking and large-scale randomised trials are urgently needed in this area. Supplementary concepts Hypothyroidism, Autoimmune. Results: Finally, 19 eligible studies including preganncy, pregnant women included for meta-analysis. Compared with untreated pregnant women, pregnant women treated with levothyroxine were significantly younger, had a lower Charlson Comorbidity Index score and had lower rates of comorbid type 2 diabetes and migraines. The analyses examined differences in characteristics and comorbidities between pregnant women treated with levothyroxine and untreated women and adherence to guidelines by measuring thyroid-stimulating hormone TSH target achievement for women treated with levothyroxine. Subclinical hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed.

Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the hypothyroidism in pregnancy pubmed database. Selection criteria: Randomised controlled trials RCTs that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism in pregnancy with another intervention or placebo. The prevalence of hyperthyroidism, clinical hyperthyroidism, and subclinical hyperthyroidism in Iranian pregnant women was respectively estimated to be 3. Publication types Review.

Among women treated with levothyroxine, Data were extracted after applying the inclusion and exclusion criteria and qualitative evaluation of the studies. Publication types Review.

Abstract Objective: Hypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Pregnancy outcomes were compared prrgnancy those of a control group of euthyroid pregnant women during the same period. This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown. In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes.

  • Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

  • Since treating clinical and subclinical hypothyroidism may reduce adverse obstetric outcomes, it is crucial to identify which interventions are safe and effective.

  • Overt hyperthyroidism during pregnancy is relatively uncommon but needs pubmed database treatment due to the increased risk of preterm delivery, congenital malformations, and fetal death. This review also showed no difference for pre-eclampsia or preterm birth when selenium was compared with placebo, however a promising reduction in postpartum thyroiditis was shown.

  • Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency.

  • There is a probable low incidence of adverse outcomes from levothyroxine and selenomethionine.

The prevalence of anti-thyroperoxidase antibody was estimated to be Data were collected from the medical records. Conclusion: The results of this meta-analysis showed a high prevalence of thyroid disorders, especially hypothyroidism. This study characterizes pregnant women with hypothyroidism and examines adherence to guidelines during pregnancy. Selenomethionine as an intervention in women with thyroid autoantibodies is promising, particularly in reducing postpartum thyroiditis. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes.

Until evidence for or against universal screening becomes available, targeted thyroid function testing in pregnancy should be implemented in women at risk of thyroid disease and levothyroxine utilised in hypothyroid women. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, but both trials reported only biochemical outcomes. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. An earlier and more individualized diagnostic assessment taking into consideration predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy.

Substances Selenomethionine Thyroxine. Selenomethionine as an intervention in women with thyroid autoantibodies is promising, particularly in reducing postpartum thyroiditis. Substances Selenomethionine Thyroxine.

We identified potential articles from the databases, and articles remained after removing the duplicate and unrelated studies. The prevalence of hyperthyroidism, clinical hyperthyroidism, and subclinical hyperthyroidism in Iranian pregnant women was respectively estimated to be 3. Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Maximum serum TSH level measured was

Recent findings: Recent observational studies have found a positive association between SCH during pregnancy pubmed database adverse maternal, neonatal and offspring outcomes, mainly in thyroid peroxidase autoantibody positive women. Objective: Hypothyroidism hypothyrpidism pregnancy has been associated with adverse obstetrical outcomes. Substances Selenomethionine Thyroxine. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. Maximum serum TSH level measured was Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

Two trials of databasr and 48 hypothyroid women respectively compared levothyroxine doses, but both trials pubmed database only biochemical outcomes. Supplementary concepts Hypothyroidism, Autoimmune. Although interventional studies have shown a benefit of levothyroxine LT4 treatment on selected pregnancy outcomes, there was no effect on offspring neurodevelopment. Main results: We included three RCTs of moderate risk of bias involving women.

Hypothyroidism in pregnancy pubmed database identified potential articles from the databases, and articles remained after removing the duplicate and unrelated studies. Additionally, there were significant differences in general health and comorbidities between pregnant women treated with hypothyroodism and those untreated. Publication types Review. None of the three trials reported on childhood neurodevelopmental delay. There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and a decreased incidence of moderate to advanced postpartum thyroiditis. Studies comparing the prevalence of miscarriage in pregnant women with SCH with those who were euthyroid were selected.

This study characterizes pregnant women with hypothyroidism and examines adherence to guidelines during pregnancy. None of the three trials reported on childhood neurodevelopmental delay. Subclinical hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed. P-value less than 0. The decision to recommend thyroid screening during pregnancy for all women is still under debate, because the positive effects of treatment on pregnancy outcomes must be ensured.

The importance of sufficient maternal thyroid supply during pregnancy is well known. Pregmancy neurodevelopmental delay was not assessed by any trial included in the review. Publication types Research Support, Non-U. Maximum serum TSH level measured was There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

None of the three trials reported on childhood neurodevelopmental delay. Results: The study group accounted for 1. Adverse pregnancy outcomes included abortions in 7.

Gov't Review Systematic Review. Selection criteria: Randomised controlled trials RCTs that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism in hypothyroidism in pregnancy pubmed database with another intervention or placebo. The effectiveness of LT4 on improving maternofetal and long-term offspring outcomes is still not fully elucidated. In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. Most cases had an autoimmune aetiology. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1.

Substances Thyrotropin Thyroxine. Two trials of 30 and 48 hypothyroid women respectively compared levothyroxine doses, hypothyroidism in pregnancy pubmed database both trials reported only biochemical outcomes. This review i the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Abstract Background: Over the last decade there has been enhanced awareness of the appreciable morbidity of thyroid dysfunction, particularly thyroid deficiency. There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable impact on postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. There is a probable low incidence of adverse outcomes from levothyroxine and selenomethionine. None of the four trials reported on childhood neurodevelopmental delay.

There was a non-significant trend towards fewer miscarriages with levothyroxine, and selenium showed some favourable dataase hypothyroidism in pregnancy pubmed database postpartum thyroid function and decreased incidence of moderate to advanced postpartum thyroiditis. The mean duration of hypothyroidism during pregnancy was In one trial of women, levothyroxine therapy to treat pregnant euthyroid women with thyroid peroxidase antibodies was not shown to reduce pre-eclampsia significantly risk ratio RR 0. A trial of women compared the trace element selenomethionine selenium with placebo and no significant differences were seen for either pre-eclampsia RR 1. Data collection and analysis: Two review authors assessed trial eligibility and quality and extracted the data.

Among women treated with levothyroxine, Subclinical hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed. Hypothyroidism in pregnancy pubmed database Review Systematic Review. Gestational transient hyperthyroidism is a self-limited non-autoimmune form of hyperthyroidism with negative antibody against TSH receptors, that is related to hCG-induced thyroid hormone secretion. None of the four trials reported on childhood neurodevelopmental delay.

Most cases had an autoimmune aetiology. All the statistical analyses were performed using Review Manager Revman Version 5. Objectives: To identify interventions used in the management of hypothyroidism and subclinical hypothyroidism in pregnancy and to ascertain the impact of these interventions on important maternal, fetal, neonatal and childhood outcomes. Childhood neurodevelopmental delay was not assessed by any trial included in the review. Data were collected from the medical records.

  • Grant support.

  • An earlier and more individualized diagnostic assessment taking into consideration predictors of thyroid dysfunction and major risk factors for complications could result in better management of SCH during pregnancy.

  • Overt and subclinical dysfunctions of the thyroid disease should be treated appropriately in pregnancy, aiming to maintain euthyroidism.

  • Data collection and analysis: Two review authors assessed darabase eligibility and quality and extracted the data. Authors' conclusions: This review found no difference between levothyroxine therapy and a control for treating pregnant euthyroid women with thyroid peroxidase antibodies for the outcome of pre-eclampsia, however a reduction in preterm birth and a trend towards reduced miscarriage with levothyroxine was shown.

  • Substances Thyrotropin Thyroxine.

Gov't Review Systematic Review. Abstract Purpose of review: Pubked hypothyroidism SCH is a common diagnosis among women of reproductive age. Summary: Current evidence strengthens the association between SCH with both maternofetal and offspring adverse outcomes. Adverse pregnancy outcomes included abortions in 7. Selection criteria: Randomised controlled trials RCTs and quasi-randomised controlled trials that compared a pharmacological intervention for hypothyroidism and subclinical hypothyroidism pre-pregnancy or during pregnancy with another intervention or placebo.

Subclinical hyperthyroidism tends to be asymptomatic and no pharmacological treatment is usually needed. Overt hyperthyroidism during pregnancy is relatively uncommon but needs hyplthyroidism treatment due to the increased risk of preterm delivery, congenital hypothyroidism in pregnancy pubmed database, and fetal death. All analyses were performed using Comprehensive Meta-Analysis Software. The prevalence of hyperthyroidism, clinical hyperthyroidism, and subclinical hyperthyroidism in Iranian pregnant women was respectively estimated to be 3. Main results: We included three RCTs of moderate risk of bias involving women. Gestational transient hyperthyroidism is a self-limited non-autoimmune form of hyperthyroidism with negative antibody against TSH receptors, that is related to hCG-induced thyroid hormone secretion.

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