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Probiotics weight loss international journal of obesity: Probiotic may boost weight loss outcomes for overweight adults: Human data

J Gastrointest Surg ; 13 : — Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production.

Ethan Walker
Wednesday, May 8, 2019
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  • LDL is heterogeneous molecule comprising a number of discrete particle subclasses that vary in size, density and cholesterol content and the small dense LDL-C sdLDL-C are considered highly atherogenic

  • Front Endocrinol ; 5 : Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity.

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Abstract Whether probiotics could be used as an adjunct to bariatric surgery is controversial. The outcomes in the study of Sherf-Dagan et al. Weight change.

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  • This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Stenman, L. Kadooka, Y.

  • The search was limited to the clinical randomized controlled trials RCTs. Br J Nutr ; 99 : —

  • Walter CanonicaJoao A. Effects of milk fermented by Lactobacillus gasseri SBT on adipocyte size in rats.

Randomized, double-blinded, placebo controlled study Country: Republic of Korea. Probiotics beneficial mechanism in host metabolism is explored Kim25 where authors propose that LGG the probiotic strain used sensitizes insulin action is co-mediated by an enhanced adiponectin production and AMPK activation and at least in part associated with increased expressions of GLUT4, and lipid oxidative genes in responsible tissues, such as adipose tissue, skeletal muscle and the liver and in Kang24 consistent with the hypothesis put forward in Kim25 reported that the anti-obesity effect of BNR17 is responsible for the increased expression of fatty acid metabolism-related genes rather than reduced fatty acid synthesis and fat intake in the liver. Individual participants in each clinical trial were the unit of analysis. This article explains what antioxidants are, how they work, and whether antioxidant supplements offer the health benefits that they claim. Randomized double-blind, controlled clinical trial.

The schedule of data and sample collection is shown in Fig. However, this review is only a preliminary exploration of probiotics in this field assisting BS weight loss and improving metabolic disorders. Claros, J. Loss international journal intfrnational the underlying causes of CVD is the incidence of atherosclerosis, an inflammatory disease of the vasculature driven by the accumulation of modified forms of LDL-C in artery walls There are several strengths in this review. Kim, and M. Outcome variables with measurements at 3 and 6 months were analysed using a linear mixed model LMM that included treatment, time, interaction between treatment and time as fixed effects, baseline measurement as a covariate, and subject as random effect.

  • Table 6.

  • Eur J Clin Nutr. Your takeaway?

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  • Totosy de Zepetnek et al. Koutnikova, B.

Diabetes ; 52 : — We also manually searched the references of included studies and previously systematic reviews to identify further relevant studies. Zhang, Q. Subgroup analyses for the effects of probiotics on TC. Paik, and S. Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives. Totosy de Zepetnek et al.

Finally, probiotics containing Lactobacillus curvatus HY significantly reduced liver fat accumulation as compared to Lactobacillus plantarum KY in diet-induced obesity. Print Email Share. Nourijelyani et al. The alteration of the gut microbiome has been widely accepted as one of the main causal factors. Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence.

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Lipopolysaccharides impair insulin gene expression in isolated islets of langerhans via toll-like receptor-4 and NF-kB signalling. J Clin Diagn Res ; 7 : — But here's the first problem: The probiotic strain highlighted in this research isn't commercially available in the U.

  • J Funct Foods ; 19 : —

  • Probiotics and their effects on metabolic diseases: an update. Probiotics have physiologic functions that contribute to the health of gut microbiota, can affect food intake and appetite, body weight and composition and metabolic functions through gastrointestinal pathways and modulation of the gut bacterial community.

  • Data Extraction Two investigators independently executed the literature search, data extraction, and quality assessment based on the eligibility criteria. Lactobacillus fermentum and Lactobacillus amylovorus as probiotics alter body weight adiposity and gut microflora in healthy persons.

  • Effects of milk fermented by Lactobacillus gasseri SBT on adipocyte size in rats. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.

  • Reilly and A.

Saccharomyces boulardii Biocodex administration reduced body weight gain and fat mass in obese and type 2 diabetic mice, and significantly changed the gut microbiota composition with an increased proportion of Bacteroidetes and a decreased amount of the phyla Firmicutes, Proteobacteria, and Tenericutes [ 56 ]. Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. The risk of bias within randomized controlled trials was independently evaluated by two investigators. Yun, M.

The influence of probiotic supplementation on gut permeability in probiotic with metabolic syndrome: an open label, randomized pilot study. Abstract Recent studies suggested that manipulation of the composition of the microbial ecosystem in the gut might be a novel approach in the treatment of obesity. Firstly, this therapy is safe, due to absence of reported adverse effects, well-tolerated and appropriate for long-term use. Effect of probiotics on TG levels showed weak significance Figure 4 d with a pooled standardized mean difference of Abstract Gut microbiota is important for maintaining body weight. Underlying mechanisms whereby the gut microbiota contributes to host metabolism were revealed from studies on germ-free mice which were protected against developing diet-induced obesity [ 1011 ]. In Europe, as forin general the incidence of obesity is high but geographically wide variations has been reported.

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Consistently, observations in mice indicate that intestinal microflora influences energy metabolism and has systemic effects on host lipid metabolism, especially triglycerides and phosphatidylcholine [ 44 ]. In Europe, as forin general the incidence of obesity is high but geographically wide variations has been reported. Chronic low-grade inflammation appears to be a major factor in the development of obesity-related metabolic disturbances [ 35 — 37 ]. The alteration of the gut microbiome has been widely accepted as one of the main causal factors.

Effect of fragmented Lactobacillus amylovorus CP on lipid metabolism in overweight and mildly obese individuals: a randomized controlled trial. Recent research has shown probiotics can aid digestion and ward off illness. In this study, only single-strain probiotic of Lactobacillus rhamnosus or Bifidobacterium breve and the mixture of Bifidobacterium breve and Lactobacillus paracasei decreased triacylglycerol content in liver and counteracted the development of hepatic steatosis in part by lowering serum LPS [ 68 ]. Table 8. The primary outcomes were body weight, body mass index BMIwaist circumference, fat mass, fat percentages, plasma lipid profiles, and glucose metabolic parameters. Prabhu et al. Facebook LinkedIn Twitter.

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Retrieved August 24, from www. Scanning reference lists of review articles, contacting content experts and contacting authors produced no extra trials. Dyslipidaemea was considered as an exclusion criteria after randomization. Differences in the alpha-diversity indices were tested using a mixed-effects linear model, implemented in the lmer function of the lme4 R package, with randomisation active or placebotime-point baseline or 6 monthsage, gender and BMI as fixed effects and each participant as a random effect. Gomes, P. Supplementary Information. Statistical analysis: Rouxinol-Dias, AL.

Zarrati, E. SCFAs such as acetate, butyrate and propionate produced by bacterial fermentation function as energy substrates, as well as regulators of satiety and food intake [ 29 ]. Figure 1. The microflora of the obese include fewer Bacteroidetes and more Firmicutes than lean people. Plaza-Diaz and coll.

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The digestive health benefits of probiotics have been widely debated. For State of Health, State of Energy, and State oof Mood, there were also significant between group benefits at 3 months of 5. All authors were involved in the conduct of the study, in interpreting the results, and in revising and correcting the manuscript. Effect of Lactobacillus gasseri SBT in fermented milk on abdominal adiposity in adults in a randomized controlled trail. Chung, H.

Canfora, J. Simon, M. Two investigators independently identified 25 articles by screening obesiry title and abstract using the eligibility criteria as described previously. Mofid, M. One of the underlying causes of CVD is the incidence of atherosclerosis, an inflammatory disease of the vasculature driven by the accumulation of modified forms of LDL-C in artery walls Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study.

Quast, C. All authors were involved in the conduct of the study, in interpreting the results, and in revising and correcting the manuscript. BMJ Open. Kadooka, M. Subgroup analyses for the effects of probiotics on BMI. Ethics declarations Competing interests The authors declare no conflict of interest.

Human intestinal microflora represents a complex ecosystem consisting of trillions of microorganisms and thousands of bacterial species that are deeply involved in different functions of host metabolism [ 17 ]. Read the research in the European Journal of Nutrition. Mice fed normal chow served as controls. You can also search for this author in PubMed Google Scholar. Johnson, J. There was a statistically significant reduction in the intervention group with a pooled standardized mean difference of Antiobesity and lipid-lowering effects of Bifidobacterium spp.

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Noda, T. Acta Diabetol. The significant reduction of at list one of the proiotics outcome endpoints which include levels of fasting plasma glucose, postprandial blood glucose, HbA1c, insulin, insulin resistance and onset of diabetes were demonstrated in all studies. Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats.

  • Prada, and J. Gomes, R.

  • Linking long-term dietary patterns with gut microbial enterotypes. Search all BMC articles Search.

  • Interestingly, ingesting more than one type of probiotic and taking probiotics for 8 weeks or more resulted in increased weight loss. Lab4P supplementation also significantly reduced the incidence of headache, earache and muscle pain although antibiotic usage did not differ between groups.

  • The gut microbiota, obesity and insulin resistance.

There are several strengths in this review. Search terms included probiotics, obesity, weight, BMI, weight gain, weight loss, weight change, probiotic diet and probiotic therapy. Only four RCTs met the inclusion criteria in our analysis, thus the power to detect the trend of overall effect in humans was limited and a chance finding cannot be excluded. Zilberman-Schapira et al. Participants were asked to complete daily diaries monitoring URTI symptoms 14 throughout the duration of the intervention period and QoLQ were completed Supplementary Fig. Two hundred and twenty participants were recruited to the study which took place between July and January Subgroup analyses for the effects of probiotics on body weight.

Lab4P supplementation also significantly reduced the incidence of headache, earache and muscle pain although antibiotic usage did not differ between groups. Subjects included; age, gender and ethnicity; classification according to initial BMI or initial abdominal circumference. Kim, and M. Seo, W. Close banner Close. Whether probiotics could be used as an adjunct to bariatric surgery is controversial. Experimental study; Country: Republic of Korea; Study groups: The mice were randomly selected and assigned to four groups mice per group according to the type of diet and test-material.

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Probiotic effect in body weight is not only species specific, but also strain specific. Br J Nutr ; : — A meta-analysis by Suzumura et al. Accepted : 25 June

John, L. Cani and N. Table 3. Buy or subscribe.

Download PDF. Awaya et al. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials. A total of 6 studies including participants consuming probiotics, not consuming probiotics evaluated the effect of probiotics supplementation on HDL-C. Huh, S. After 10 weeks, the average body weight was 11 percent lower p Park

  • Effect of probiotics on TG levels showed weak significance Figure 4 d with a pooled standardized mean difference of

  • Figure 5.

  • HeppnerSamuel ChiangSara G. Pedret, A.

  • Lipids Health Dis ; 15 :

  • Michael, A.

  • Mol Aspects Med.

BMJ Open. Read the winning articles. Even though scientists are still investigating how probiotics work in the body, research has shown that they play a role in enhancing immune function, decreasing inflammationand positively impacting nervous system function. One study did not report the species and dose of probiotics supplementation. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. Burgert et al.

We also searched for completed and ongoing trials latest search 7 August in the following registers: ClinicalTrials. Loxley, J. Food Sci. Eligible 75 ,randomized 75allocated for intervention 25 allocated for control group 25loss of follow-up in intervention group 2. Gut microbiome and body weight.

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All randomized controlled trials RCTs on the effects of probiotics in adults with obesity after bariatric surgery were analyzed according to the eligibility criteria. The digestive health benefits of probiotics have been widely debated. A systematic review and meta-analysis that included articles and 6, participants also found that probiotic treatment led to reductions in body fat, waist circumference, and BMI. Judgements about the risk of bias items across all are shown in Figure 2 b.

No particular study significantly affected the pooled effect of probiotics on glucose metabolic parameters fasting plasma glucose, HbA1c, and HOMA-IR by sensitivity analyses. Lee, S. Chung, C. Liu, et al.

Richness of human gut microbiome correlates with metabolic markers. The researchers looked at all available studies on body mass index BMI and Bifidobacterium adolescentis supplementation ameliorates visceral fat accumulation and insulin sensitivity in an experimental model of the metabolic syndrome. Zhao, and Y. Taking into account all these data the concept of manipulating the gut microbiota to improve host metabolism has gained considerable interest nowadays. And a new study, published in the British Journal of Nutrition, links one probiotic strain to fat loss. Noda, T.

Forest plot presenting the effects of probiotic supplementation on the changes of CRP in patients at a 3 months and b 12 months after bariatric surgery, respectively. The last search was run on 3 May Hadi, G. Cochrane handbook for systematic reviews of interventions version 5.

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PLoS One ; 4 boesity e Data Extraction Two investigators independently executed the literature search, data extraction, and quality assessment based on the eligibility criteria. While everyone consumed a daily 7-ounce serving of fermented milk, two of the groups drank milk spiked with varying amounts of a probiotic called Lactobacillus gasseri SBTwhich past research has tied to fat loss.

Int J Obes ; 36 : — Our meta-analysis found no change in WC infernational 3 months after probiotics use and a significant decrease at 12 months. Full Text. Possibly, BS has a massive impact on obesity and metabolism; hence, the minor role of probiotics is hidden. View author publications. Zarrati

Related articles. In recent years, intestinal microflora has received increasing attention as a metabolic gateway between the outer environment and the host, particularly with regard to modulation of inflammation, energy metabolism and body weight homeostasis. Finally, treatment with A. Forest plot of effect of probiotics on a body weight; b BMI; c waist circumference; d fat mass; e fat percentage.

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Participant perceived quality of life QoL and the incidence of upper respiratory tract infection URTI international journal monitored as indicators of general well-being with stratification of the study population to identify subgroups of participants benefitting most from probiotic supplementation. Impact of worsened metabolic syndrome on the risk of dementia: A nationwide cohort study. Are you a health professional able to prescribe or dispense drugs? During the four studies, the participants were not operated on the same BS.

Rev Bras Cienc Farm ; internayional : 1— Data from clinical studies are summarized in Table 2. The probiotics might also reduce the opportunistic pathogens and their metabolites, such as trimethylamine TMALPS, and indole [ 37 ]. Transl Res. Mol Aspects Med. Future Microbiol ; 7 : 91— Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.

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Randazzo, C. Stoltzfus, and M. Yu, et al. Kim, M. Bibin, D.

Costs obesity, M. Massaro, U. Our study is one of the first to report the impact of a multi-strain probiotic on weight loss in response to 6-months supplementation in a cohort wekght healthy, overweight and obese, free-living no dietary or lifestyle restrictions subjects. In this Special Feature, we give an overview of the communities of microorganisms, called microbiota, that form a symbiotic whole with our human cells. Modulation of gut microbiota by probiotics may result in weight loss and thus help in obesity treatment. Experimental study; Country: Republic of Korea; Study groups: The mice were randomly selected and assigned to six groups 8 mice per group according to the type of diet and test-material. Arora, S.

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Microb Ecol Health Dis ; 12 : — In order to get an accurate international journal, the studies in which internationnal consumed prebiotics, synbiotics, herb, and other supplements such as micronutrients or other dietary constituents were excluded as the effects of probiotics supplementation from those supplementations could not be distinguished; also the possible interaction between probiotics supplementation and those supplementations was excluded. The criteria used by WHO to diagnose obesity is the body mass index BMI : A person with a BMI greater or equal to 25 is considered overweight; greater or equal to 30 is considered as having obesity. Microbes are commonly associated with disease, but there are millions inside the human body, and some provide distinct benefits.

Different from studies on patients with diabetes or other metabolism syndromes [ 27 ], there was also probiotisc significant reduction in fat us health care costs obesity and fat percentage in healthy adults. Your takeaway? One of the potential ideal strategy for obesity treatment may be manipulation with gut microbiota. Effects on Total Cholesterol TC. After 12 weeks, people slugging the probiotic milk formulas dropped roughly 8 to 9 percent of their visceral fat —a particularly unhealthy type that builds up around your heart and organs. Any disagreements were resolved by discussion between data collectors alone with a third investigator. Your takeaway?

Experimental study; Internatonal Republic of Korea; Study groups: The mice were randomly selected and assigned to four groups, each with two subgroups 10 mice per group according to the type of diet and test-material. Jung, S. Karbaschian, A. A review of probiotic supplementation in healthy adults: helpful or hype? Johnson, J. Schulz, D. Present Control of probiotic intervention with L.

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Lipopolysaccharides impair insulin gene expression in isolated islets of langerhans via toll-like receptor-4 welght NF-kB signalling. Pages March - April To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. The last search was run on 3 May Symonds, and M.

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. After 10 weeks, the average body weight was probiotics weight loss international journal of obesity percent prboiotics p Park 15 Experimental study; Country: Republic of Korea; Study groups: The mice were randomly selected and assigned to four groups, each with two subgroups 10 mice per group according to the type of diet and test-material. Eligible 75 ,randomized 75allocated for intervention 25 allocated for control group 25loss of follow-up in intervention group 2. Fact sheet: Obesity and Overweight, n. Lipids Health Dis, 10pp. Diabetes ; 52 : — Cite this article Crovesy, L.

Transl Res. Today's Top Stories. Figure 1. Linking long-term dietary patterns with gut microbial enterotypes. As a kind of active microorganism, the probiotics regulate the onesity microecosystem, improve the gut microecosystem and the host energy metabolism, and reduce the chronic inflammation and oxidative stress [ 489 ]. Subgroup analyses Table 8 stratified by probiotics dosage and the number of probiotics strains indicated the effects of probiotics supplementation on LDL-C were significantly reduced in trials with multiple strain probiotics

Rights and permissions Reprints and Permissions. Kim, E. A systematic research review.

All prices probiotics weight loss international journal of obesity NET prices. Saccharomyces boulardii Biocodex administration reduced body weight gain and fat mass in obese and type 2 diabetic mice, and significantly changed the gut internatiobal composition with an increased proportion of Bacteroidetes and a decreased amount of the phyla Firmicutes, Proteobacteria, and Tenericutes [ 56 ]. Effects on Insulin. Prebiotics and probiotics are of interest because they have been shown to alter the composition of gut microbiota and to affect food intake and appetite, body weight and composition and metabolic functions through gastrointestinal pathways and modulation of the gut bacterial community [ 7071 ].

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Article Google Scholar 5. Several other probiotic strains have been tested as agents with potential antidiabetic effects. Lean and obese children harbor different types of microbes. A total of 6 studies including participants consuming probiotics, not consuming probiotics evaluated the effect of probiotics supplementation on insulin Figure 5 c. Cani and N. Tax calculation will be finalised during checkout. Of note, the presence of obesity-related metabolic disturbances varies widely among obese individuals [ 48 ].

Sanchez Published : 10 July Besides, the survivability and stability of probiotics, influenced by the manufacturers, could also affect the clinical outcomes. All authors were involved in the conduct of the study, in interpreting the results, and in revising and correcting the manuscript. Plummer, I.

Seven studies among participants consuming probiotics, not consuming probiotics reported the changes of LDL-C Figure 4 c. Microb Ecol Health Dis ; 27 : Bell, et al. Already being considered the fifth leading risk factor for global deaths, obesity kills at least 2.

Participants who received higher probioics of probiotics and those who received a single strain rather than multiple strain probiotics saw greater body fat loss. All randomized controlled trials RCTs on the effects of probiotics in adults with obesity probiotics weight loss international journal of obesity bariatric surgery were analyzed according to the eligibility criteria. Two investigators independently identified 25 articles by screening the title and abstract using the eligibility criteria as described previously. References P. Some scientists have raised concerns over the widespread use of probiotic supplements and warn that they know little about the long-term safety of probiotic supplements. Experimental study; Country: Republic of Korea; Study groups: The mice were randomly selected and assigned to two groups, each with two subgroups mice per group according to the type of diet and test-material. The review found that most of these improvements resulted from treatments containing bifidobacteria B.

These four experiments had short follow-up time. Sensitivity analyses revealed loes no particular studies significantly affected the summary effects of body weight. Because there were no studies that reported the effect of probiotics on TC in the form of food, subgroup analyses Table 6 only stratified by probiotics dosage and the number of probiotics strains indicated the effects of probiotics supplementation on TC were significantly reduced in trials with single strain probiotics Elinav, C. Correspondence to D. All prices are NET prices. Ding, and L.

This suggests that these microbial strains can be applied in the treatment of obesity. Show results from All journals This journal. Contact us Submission enquiries: Access here and click Contact Us General enquiries: info biomedcentral.

Effect of Lactobacillus plantarum v on cardiovascular disease risk factors in smokers. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. Meta-analysis was performed using RevMan5. One study did not report the species and dose of probiotics supplementation. Park, C.

This possible stabilization in the obesity trends interhational be an early sign of a plateau in the obesity epidemic. The probiotics might also reduce the opportunistic pathogens and their metabolites, such as trimethylamine TMALPS, and indole [ 37 ]. Microbes in gastrointestinal health and disease. We also manually searched the references of included studies and previously systematic reviews to identify further relevant studies. Effect of probiotics on TG levels showed weak significance Figure 4 d with a pooled standardized mean difference of

Background

Internaional of probiotics on HOMA-IR level was shown to be statistically significant, with a pooled standardized mean difference of Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives. Baseline demographics of the participants are shown in Table 1. Jin et al.

The role of probiotics and prebiotics in the prevention and treatment of obesity. Inhernational quality clinical studies are needed to confirm the efficacy and safety of probiotics and address a number of practical issues before the routine clinical use of probiotics in adults with obesity undergoing BS. Probiotics are amongst the most popular nutrition supplements on the market. Zhao, and Y. Lim et al. Table 2.

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and lloss in Bifidobacterium animalis and Methanobrevibacter smithii. Academic Editor: Evan P. On the other hand L. In the most recent meta-analyses detailing probiotics and weight loss, body weight reductions up to 1. Kerry-Smith, J. Studies including patients who had undergone any other gastrointestinal surgeries were excluded.

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Downey et al. Results 3. Adams, F. Targeting the microbiota to address diet-induced obesity: a time dependent challenge.

  • Eight studies, among participants consuming probiotics, not consuming probioticsreported the effect of probiotics supplementation on waist circumference Figure 3 c.

  • Richness of human gut microbiome correlates with metabolic markers.

  • Data extracted from included human studies 4 RCTs. Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives.

  • Fontaine, K. All authors were involved in the conduct of the study, in interpreting the results, and in revising and correcting the manuscript.

Sensitivity analyses revealed that no particular studies significantly affected the summary effects of BMI. This study firstly assessed the effects of probiotics on obesity and the associated clinical indicators, such as plasma lipid profiles and glycaemic parameters. Search Search articles by subject, keyword or author. Reprints and Permissions.

European Journal of Nutrition To obtain the best experience, we internatinoal you use a more up to date browser or turn off compatibility mode in Internet Explorer. The funnel plots were presented in Figure S1. Effect of probiotics on HOMA-IR level was shown to be statistically significant, with a pooled standardized mean difference of

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The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperature that have paralleled the socioeconomic loss international of the past decades [ 13 ]. Afghanistan updates: Taliban warns of 'serious position' if US stays beyond Aug. In a study, Frida Karlsson Videhult and colleagues at Umea University in Sweden asked whether infants fed with lactobacilli would have long-term effects in body composition, growth and other biomarkers. The amount of these bacteria negatively correlates with body weight and decreases in response to a HFD [ 56 ].

  • More quality clinical studies are jnternational to confirm the efficacy and safety of probiotics and address a number of practical issues before the routine clinical use of probiotics in adults with obesity undergoing BS. There was no significant selection bias, performance bias, detection bias, attrition bias, reporting bias, or other biases detected among the included trials Figure 2.

  • Current research efforts have focused on host and environmental factors that may affect energy balance.

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  • Effects on Hemoglobin A1c HbA1c.

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Two investigators independently obesity the literature search, data extraction, and quality assessment based on the eligibility criteria. You may be able to find more information about this and similar content at piano. Insulin sensitivity, insulin secretion, and abdominal fat: the insulin resistance atherosclerosis study IRAS family study. Secondary, modulation of gut microbiota by probiotic treatment or dietary intervention due to it beneficial effects can affect body weight, influence on glucose and fat metabolism, improve insulin sensitivity and reduce chronic systemic inflammation. Interesting findings were demonstrated in study reported by Shavakhi et al. Lipopolysaccharides impair insulin gene expression in isolated islets of langerhans via toll-like receptor-4 and NF-kB signalling. Correspondence to L Crovesy.

Kim, and M. A total of 4 clinical trials and 14 experimental studies were included in the systematic review. Regulation of abdominal adipocity by probiotics Lactobaacillus gasseri SBT in adults with obese tendencies in a randomized controlled trial. Altman, D. Three of the four RCTs had high risk of bias in blinding of outcome Fig. The longer intervention duration is associated with weight loss, inferring from several other meta-analyses [ 5152 ]. Download PDF Bibliography.

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